TITLE

SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population

AUTHOR(S)
Chih-Jen Huang; Shi-Long Lian; Ming-Feng Hou; Chee-Yin Chai; Yi-Hsing Yang; Sheng-Fung Lin; Hsueh-Wei Chang
PUB. DATE
October 2014
SOURCE
Cancer Cell International;2014, Vol. 14 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity. Results In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not associated with clinicopathologic features of angiogenesis such as VEGF activity and the micro-vessel density and survival of breast cancer patients. Conclusion Taken together, the 1772 C > T of HIF-1α gene is a potential biomarker for breast cancer susceptibility.
ACCESSION #
98703903

 

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