Temozolomide (Temodarâ„¢)

Bruce, Susan
January 2001
Clinical Journal of Oncology Nursing;Jan/Feb2001, Vol. 5 Issue 1, p3
Academic Journal
Presents information on the alkylating agent temozolomide. Commercial name of temolozomide from Schering Corporation; Indication; Effect on blood count.


Related Articles

  • Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum. Sandercock, Linda E.; Kwok, Melvin C. H.; Luchman, H. Artee; Mark, Sean C.; Giesbrecht, Jennette L.; Samson, Leona D.; Jirik, Frank R. // Oncogene;8/5/2004, Vol. 23 Issue 35, p5931 

    O:6-methylguanine methyltransferase, Mgmt, constitutes the first line of defense against O6-alkylguanine, which can result in G?:?C to A?:?T transitions upon DNA replication. Mgmt has been found in organisms as diverse as archaebacteria and mammals. This evolutionary conservation suggests that...

  • PM00104 (Zalypsis®): A Marine Derived Alkylating Agent. Petek, Bradley J.; Jones, Robin L. // Molecules;Aug2014, Vol. 19 Issue 8, p12328 

    PM00104 (Zalypsis®) is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding...

  • Alkylating ability of artemisinin after Cu(I)-induced activation. Bousejra-El Garah, Fatima; Pitié, Marguerite; Vendier, Laure; Meunier, Bernard; Robert, Anne // Journal of Biological Inorganic Chemistry;Apr2009, Vol. 14 Issue 4, p601 

    The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin–copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is...

  • Ir/Sn dual-reagent catalysis towards highly selective alkylation of arenes and heteroarenes with benzyl alcohols. Roy, Sujit; Podder, Susmita; Choudhury, Joyanta // Journal of Chemical Sciences;Sep2008, Vol. 120 Issue 5, p429 

    A catalytic combination of [Ir(COD)Cl]2-SnCl4 efficiently promotes the reactions of arenes and heteroarenes with 1°/2°/3° benzyl alcohols as the alkylating agents to afford the corresponding diarylmethane and triarylmethane derivatives in high yields. The scope and limitation of the...

  • Ambamustine: PTT119.  // Drugs in R&D;2003, Vol. 4 Issue 2, p119 

    Provides information on ambamustine, a bifunctional alkylating agent from Mundipharma Proter. Features and properties; Properties of ambamustine when tested against the L1210 leukemia cells; Drug development history.

  • Th2/Th1 switch induced by a single low dose of cyclophosphamide in a rat metastatic lymphoma model. Matar, Pablo; Rozados, Viviana R.; Gervasoni, Silvia I.; Scharovsky, Graciela O. // Cancer Immunology, Immunotherapy;Jan2002, Vol. 50 Issue 11, p588 

    Cyclophosphamide (Cy) is an alkylating agent widely used in cancer chemotherapy. It has a bimodal effect on the immune system, depending on the dose and schedule of administration. We have previously demonstrated that a single low dose of Cy has an antimetastatic effect, achieved through...

  • Cardio-respiratory effects of DRDE-07, a new prophylactic agent for sulphur mustard toxicity, in anesthetized rats. Malviya, V.; Singh, R.; Kumar, D.; Pathak, U.; Kumar, P.; Jaiswal, D. K.; Mathur, R.; Vijayaraghavan, R. // Indian Journal of Pharmacology;Aug2004, Vol. 36 Issue 4, p234 

    Objective: To study the cardio-respiratory effects of DRDE-07, a new prophylactic agent for sulphur mustard. Material and Methods: The effect of DRDE-07 was studied in anesthetized male rats (Wistar), by administering it either by intraperitoneal or oral routes. Different doses (0.25, 0.5, 1.0...

  • Balancing repair and tolerance of DNA damage caused by alkylating agents. Fu, Dragony; Calvo, Jennifer A.; Samson, Leona D. // Nature Reviews Cancer;Feb2012, Vol. 12 Issue 2, p104 

    Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch...

  • ALKYLATION OF 4-R-SUBSTITUTED-2H-PHTHALAZINE-1-ONES. BOBOVA, T. A.; SHETNEV, A. A.; CHERKALIN, M. S.; KOLOBOV, A. V.; PLAKHTINSKIY, V. V. // Izvestiya Vysshikh Uchebnykh Zavedenii. Seriya Khimiya i Khimich;2011, Vol. 54 Issue 11, p41 

    By the interaction of 4-R-substituted-2H-phthalazine-1-ones with alkylating agents of different activity the series of new derivatives of NH ftalazinona was synthesized.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics