Temozolomide (Temodar�)
Tags: ALKYLATING agents; SCHERING AG; CHEMICAL tests & reagents; CARCINOGENS; MUTAGENS
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- Alkylating ability of artemisinin after Cu(I)-induced activation. Bousejra-El Garah, Fatima; Piti�, Marguerite; Vendier, Laure; Meunier, Bernard; Robert, Anne // Journal of Biological Inorganic Chemistry;Apr2009, Vol. 14 Issue 4, p601
The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin�copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is...
- Ir/Sn dual-reagent catalysis towards highly selective alkylation of arenes and heteroarenes with benzyl alcohols. Roy, Sujit; Podder, Susmita; Choudhury, Joyanta // Journal of Chemical Sciences;Sep2008, Vol. 120 Issue 5, p429
A catalytic combination of [Ir(COD)Cl]2-SnCl4 efficiently promotes the reactions of arenes and heteroarenes with 1�/2�/3� benzyl alcohols as the alkylating agents to afford the corresponding diarylmethane and triarylmethane derivatives in high yields. The scope and limitation of the...
- Balancing repair and tolerance of DNA damage caused by alkylating agents. Fu, Dragony; Calvo, Jennifer A.; Samson, Leona D. // Nature Reviews Cancer;Feb2012, Vol. 12 Issue 2, p104
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage. Numerous cellular pathways, including direct DNA damage reversal, base excision repair (BER) and mismatch...
- Reactions of 3-nitro-1,2,4-triazole derivatives with alkylating agents. 8*. Alkylation of 3-nitro-5-R-1,2,4-triazoles with derivatives of diethylene glycol in the presence of alkali. Sukhanov, G. T.; Sakovich, G. V.; Sukhanova, A. G.; Filippova, J. V.; Oleshchenko, J. Yu. // Chemistry of Heterocyclic Compounds;Apr2011, Vol. 47 Issue 1, p55
The interaction of 3-nitro-1,2,4-triazole and 5-methyl-3-nitro-1,2,4-triazole with bifunctional agents - β,β′-dichloro- and β,β′-(dinitroxy)diethyl ethers - in the presence of alkali proceeds with the formation of a mixture of products substituted at the N(1) and N(2) atoms of the...
- ALKYLATION OF 4-R-SUBSTITUTED-2H-PHTHALAZINE-1-ONES. BOBOVA, T. A.; SHETNEV, A. A.; CHERKALIN, M. S.; KOLOBOV, A. V.; PLAKHTINSKIY, V. V. // Izvestiya Vysshikh Uchebnykh Zavedenii. Seriya Khimiya i Khimich;2011, Vol. 54 Issue 11, p41
By the interaction of 4-R-substituted-2H-phthalazine-1-ones with alkylating agents of different activity the series of new derivatives of NH ftalazinona was synthesized.
- ALKYLATION OF 4-R-SUBSTITUTED-2H-PHTHALAZINE-1-ONES. BOBOVA, T. A.; SHETNEV, A. A.; CHERKALIN, M. S.; KOLOBOV, A. V.; PLAKHTINSKIY, V. V. // Izvestiya Vysshikh Uchebnykh Zavedenii. Seriya Khimiya i Khimich;2011, Vol. 54 Issue 11, p157
By the interaction of 4-R-substituted-2H-phthalazine-1-ones with alkylating agents of different activity the series of new derivatives of NH ftalazinona was synthesized.
- Temozolomide-Associated Organizing Pneumonitis. Maldonado, Fabien; Limper, Andrew H.; Lim, Kaiser G.; Aubry, Marie-Christine // Mayo Clinic Proceedings;Jun2007, Vol. 82 Issue 6, p771
Temozolomide is an oral alkylating agent recently approved for the treatment of glioblastoma multiforme. It has a favorable side effect profile and is generally well tolerated. Although mild respiratory symptoms have been described, pulmonary toxicity that requires discontinuation of therapy is...
- Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Chen, Yijing; Yee, Della; Dains, Katherine; Chatterjee, Aurobindo; Cavalcoli, James; Schneider, Elizabeth; Om, Jinsop; Woychik, Richard P.; Magnuson, Terry // Nature Genetics;Mar2000, Vol. 24 Issue 3, p314
The ability to generate mutations is a prerequisite to functional genetic analysis. Despite a long history of using mice as a model system for genetic analysis, the scientific community has not generated a comprehensive collection of multiple alleles for most mouse genes. The chemical mutagen of...
- National Toxicology Plan Unveiled. Henig, Robin Marantz // BioScience;Oct1979, Vol. 29 Issue 10, p631
The article offers information on the National Toxicology Program (NTP), established in November 1978 by Joseph Califano in the U.S. It is mentioned that the plan was revealed on August 10, 1979. The nine-member executive committee for NTP comprises of representatives from regulatory and...
