TITLE

Predominance of Rotavirus G1[P8] Genotype among Under-Five Children with Gastroenteritis in Mwanza, Tanzania

AUTHOR(S)
Hokororo, Adolfine; Kidenya, Benson R.; Seni, Jeremiah; Mapaseka, Seheri; Mphahlele, Jeffrey; Mshana, Stephen E.
PUB. DATE
October 2014
SOURCE
Journal of Tropical Pediatrics;Oct2014, Vol. 60 Issue 5, p393
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We analyzed stool samples from underfives with gastroenteritis for rotavirus infection between January 2010 and June 2011. A total of 393 stool specimens were examined for rotavirus infection using enzyme-linked immunosorbent assay (ELISA). Hundred selected positive specimens were genotyped using multiplex polymerase chain reaction. Out of 393 underfives, 194 (49.4%) had rotavirus infection, with 96.9% of infected underfives being <2 years. Underfives infected with rotavirus had prolonged hospital stay than those without rotavirus infection (P = 0.0001). G1 was the most predominant G type (59%) followed by G8 (13%) while P[8] was the most predominant P type (25%). In single-type infection, common G–P combinations were G1P[8] (24%) and G1P[6] (17%). Common mixed infections were G1/G8 (16%) and P4/P8 (13%). G1 genotype is common among underfives with gastroenteritis in Mwanza. Diversity of genotypes causing gastroenteritis in Mwanza necessitates a continuous surveillance after the introduction of RotaRix® vaccine.
ACCESSION #
98637438

 

Related Articles

  • Rotavirus and Norovirus infections among acute gastroenteritis children in Morocco. El Qazoui, Maria; Oumzil, Hicham; Baassi, Larbi; El Omari, Nezha; Sadki, Khalid; Amzazi, Saaid; Benhafid, Mohamed; El Aouad, Rajae // BMC Infectious Diseases;2014, Vol. 14 Issue 1, p1 

    Background Acute gastroenteritis is a serious cause of child mortality and morbidity in resource-limited countries. A viral etiology is most common, and rotavirus and norovirus are reported to be the leading causative agents. There are still few epidemiological data on the simultaneous...

  • Human Bocavirus in Children Hospitalized for Acute Gastroenteritis: A Case-Control Study. Wei-xia Cheng; Yu Jin; Zhao-jun Duan; Zi-qian Xu; Hong-mei Qi; Qing Zhang; Jie-mei Yu; Lin Zhu; Miao Jin; Na Liu; Shu-xian Cui; Hui-ying Li; Zhao-yin Fang // Clinical Infectious Diseases;7/15/2008, Vol. 47 Issue 2, p161 

    Background. Human bocavirus (HBoV) was recently discovered in children with respiratory tract disease and gastroenteritis. The causative role of HBoV in human gastroenteritis remains uncertain, and, to our knowledge, no previous case-control study has studied the relationship between HBoV and...

  • Rotavirus Gastroenteritis in Children in 4 Regions in Brazil: A Hospital-Based Surveillance Study. Munford, Veridiana; Gilio, Alfredo Elias; de Souza, Eloisa Correa; Cardoso, Debora Morais; Cardoso, Divina das Dores de Paula; Borges, Ana Maria Tavares; da Costa, Paulo Sergio Sucasas; Melgaço, Irene Angela Melo; Rosa, Humberto; Carvalho, Paulo Roberto Antonacci; Goldani, Marcelo Zubaran; Moreira Jr.,, Edson Duarte; Santana, Ciria; El Khoury, Antoine; Ikedo, Fabio; Rácz, Maria Lucia // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS106 

    Background. Rotavirus is a major cause of gastroenteritis in children. Knowledge of rotavirus genotypes is important for vaccination strategies. Methods. During 2005-2006, rotavirus surveillance studies were conducted in São Paulo, Salvador, Goiânia, and Porto Alegre, Brazil. Stool samples...

  • Comparison of Enzyme-Linked Immunosorbent Assay and Immunochromatography for Rotavirus Detection in Children Below Five Years with Acute Gastroenteritis. DHIMAN, SHAVETA; DEVI, BIMLA; SINGH, KARNAIL; DEVI, PUSHPA // Journal of Clinical & Diagnostic Research;Sep2015, Vol. 9 Issue 9, p6 

    Background: Group-A rotaviruses are responsible for 30 to 60% of severe watery diarrhea cases in young children. Timely diagnosis of rotavirus infection helps to determine appropriate treatment and prevents unnecessary use of antibiotics. Aim: To compare Immunochromatography (ICG) with standard...

  • Epidemiology of Rotavirus Diarrhea in Mongolia and Sri Lanka, March 2005-February 2007. Nyambat, Batmunkh; Gantuya, Sengee; Batuwanthudawe, Ranjith; Wijesinghe, Pushpa R.; Abeysinghe, Nihal; Galagoda, Geethani; Kirkwood, Carl; Bogdanovic-Sakran, Nada; Jung Oak Kang; Kilgore, Paul E. // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS160 

    Background. Rotavirus is the most common cause of severe gastroenteritis among children. We conducted hospital-based surveillance to estimate the burden of hospitalizations for rotavirus among children aged <5 years and to describe strain distribution patterns during the 2-year study period....

  • Sentinel Hospital-Based Surveillance of Rotavirus Diarrhea in Iran. Eesteghamati, A.; Gouya, M.; Keshtkar, A.; Najafi, L.; Zali, M. R.; Sanaei, M.; Yaghini, F.; el Mohamady, H.; Patel, M.; Klena, J. D.; Teleb, N. // Journal of Infectious Diseases;11/2/2009, Vol. 200 Issue S1, pS244 

    Background. Rotavirus is the most common causes of severe, acute diarrhea during childhood and is an important cause of morbidity and mortality in developing countries. We established active hospital-based surveillance of childhood diarrhea to assess the scope of severe rotavirus disease in...

  • Rotavirus Infections among HIV-Infected Children in Nairobi, Kenya. Kiulia, Nicholas M.; Nyaundi, Julia K.; Peenze, Ina; Nyachieo, Atunga; Musoke, Rachel N.; Steele, Andrew D.; Mwenda, Jason M. // Journal of Tropical Pediatrics;Oct2009, Vol. 55 Issue 5, p318 

    Human rotaviruses have emerged as a leading cause of acute diarrhea in children <5 years of age worldwide. Although there are previous reports relating to various aspects of rotaviruses, there is limited data on the involvement of rotavirus infection in HIV-infected children. We therefore...

  • Antibiotic Treatment Suppresses Rotavirus Infection and Enhances Specific Humoral Immunity. Uchiyama, Robin; Chassaing, Benoit; Zhang, Benyue; Gewirtz, Andrew T. // Journal of Infectious Diseases;Jul2014, Vol. 210 Issue 2, p171 

    Background. Rotavirus causes 500 000 deaths and millions of physician visits and hospitalizations per year, with worse outcomes and reduced vaccine efficacy in developing countries. We hypothesized that the gut microbiota might modulate rotavirus infection and/or antibody response and thus...

  • A prospective evaluation of community acquired gastroenteritis in paediatric practices: impact and disease burden of rotavirus infection. Frühwirth, M.; Karmaus, W.; Moll-Schüler, I.; Brösl, S.; Mutz, I. // Archives of Disease in Childhood;May2001, Vol. 84 Issue 5, p393 

    Aims--To examine the disease burden and epidemiology of community acquired rotavirus gastroenteritis in Austrian children treated in a paediatric practice. Methods--A prospective, population based, multicentre study in four paediatric practices and two children's hospitals (Innsbruck and...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics