Salivary Proteomics: Current Status & Future Perspectives

Rath, Saroj Kumar; Kosala, Manab; Ray, Brig S. K.
September 2014
Indian Journal of Dental Sciences;Sep2014, Vol. 6 Issue 3, p107
Academic Journal
Analysis of saliva may offer a cost-effective approach to assessment of oral and systemic diseases. Apart from proteomic markers, saliva is a pool wherein various genomic and microbiological markers are also found. Currently, inflammatory mediators and other hostderived enzymes hold the greatest promise as salivary diagnostic tests for oral diseases. Longterm longitudinal studies, however, are required to quantify the relationship between specific markers with progression of any oral disease. The biomarkers can be obtained from blood components such as: serum or plasma. However because of it's being an invasive procedure other body fluids such as saliva and GCF are being considered for potential source of biomarkers. The simple and non- invasive nature of saliva collection and its high sensitivity assay development has led to the salivary biomarkers being a promising future for periodontal diagnosis. Further technological advancement and identification of robust and discriminatory sets of salivary biomarkers is necessary to fulfill all requirements for being regular diagnostic tool for the everyday clinical practice. Despite limitations we experience today, the use of saliva for diagnostic purposes becomes increasingly popular, and as a result, more and more diagnostic tests become commercially available, and are currently used by clinicians and researchers.


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