An evaluation of heart rate variability and its modifying factors in children with type 1 diabetes

Özgür, Senem; Ceylan, Özben; Şenocak, Filiz; Örün, Utku A.; Doğan, Vehbi; Yılmaz, Osman; Keskin, Mahmut; Aycan, Zehra; Okutucu, Sercan; Karademir, Selmin
October 2014
Cardiology in the Young;Oct2014, Vol. 24 Issue 5, p872
Academic Journal
Objective: To evaluate heart rate variability by Holter monitoring in type 1 diabetic children compared with a healthy control group and determine the factors modifying heart rate variability. Methods: This was designed as a prospective study comparing 28 patients, diagnosed with type 1 diabetes and under follow-up, with 27 healthy control group subjects. Results: The patients were aged 9.9 ± 4.2 years in the diabetic group, including 13 (46.5%) girls and 15 (53.5%) boys. The healthy control group comprised 20 (74%) girls and seven boys (26%) with an average age of 8.6 ± 3.7 years. The search for factors modifying heart rate variability yielded the following correlations: for the time-dependent variables, negative between age and both average and maximal heart rate (r = −0.263 and −0.460, respectively), negative between haemoglobin A1c and percentage of differences between adjacent RR intervals >50 ms, positive between diabetes duration and square root of the mean of the sum of squares of differences between adjacent NN intervals. The average heart rate and percentage of differences between adjacent RR intervals >50 ms was significantly higher in the girls than the boys in all groups. With regard to the frequency-dependent factors affecting heart rate variability, correlations were found between haemoglobin A1c level and both total power and very low frequency (r = −0.751 and −0.644) and between very low frequency and diabetes duration. Conclusion: A reduction in heart rate variability parameters was observed in type 1 diabetes mellitus patients who had a long disease duration or were poorly controlled, as compared with healthy controls.


Related Articles

  • Impact of metformin on peak aerobic capacity. Braun, Barry; Eze, Pamela; Stephens, Brooke R.; Hagobian, Todd A.; Sharoff, Carrie G.; Chipkin, Stuart R.; Goldstein, Benjamin // Applied Physiology, Nutrition & Metabolism;Feb2008, Vol. 33 Issue 1, p61 

    Individually, exercise and the drug metformin have been shown to prevent or delay type 2 diabetes. Metformin mildly inhibits complex I of the electron transport system and may impact aerobic capacity in people exercising while taking metformin. The purpose of the study was to evaluate the...

  • Insulin-based therapies in type 2 diabetes.  // Journal of Endocrinology, Metabolism & Diabetes of South Africa;Mar2012, Vol. 17 Issue 1, pS32 

    The article presents several studies conducted on examining the insulin-based therapies in type 2 diabetes. One study reveals that patients with type 2 diabetes assigned to receive a basal, biphasic or prandial insulin regimen, the mean glycated haemoglobin levels at one year were similar in the...

  • Should GPs lower HbA1c targets? Moberly, Tom // GP: General Practitioner;5/7/2010, p26 

    The article focuses on the debate that whether hemoglobin A1c (HbA1c) targets should be lowered or not in patients with type-2 diabetes. It states that action to control cardiovascular risk in diabetes (ACCORD) study published in the 2010 issue of the periodical "Diabetes Care" reveals that...

  • Success with lifestyle monotherapy in youth with new-onset type 2 diabetes. Wittmeier, Kristy D. M.; Wicklow, Brandy A.; Sellers, Elizabeth A. C.; Griffith, Angella T. R.; Dean MD, Heather J.; McCavock, Jonathan M. // Paediatrics & Child Health (1205-7088);Mar2012, Vol. 17 Issue 3, p129 

    BACKGROUND: Evidence is lacking to support the efficacy of lifestyle modification as first-line therapy in the clinical management of type 2 diabetes mellitus (T2DM) in adolescents. METHODS: A retrospective chart review of youth diagnosed with T2DM between 1999 and 2008 was conducted. The...

  • Lower A1c among adolescents with lower perceived A1c goal: a cross-sectional survey. Clements, Scott A.; Anger, Matthew D.; Bishop, Franziska K.; McFann, Kim K.; Klingensmith, Georgeanna J.; Maahs, David M.; Wadwa, Raj Paul // International Journal of Pediatric Endocrinology;2013, Vol. 2013 Issue 1, p1 

    Background The International Society for Pediatric and Adolescent Diabetes (ISPAD) and the American Diabetes Association (ADA) have established a hemoglobin A1c (A1c) target of less than 7.5% for adolescents with type 1 diabetes (T1D). However, many adolescents are unaware of their A1c target,...

  • Comparison of effect of metformin in combination with glimepiride and glibenclamide on glycaemic control in patient with type 2 diabetes mellitus. Shimpi, R. D.; Patil, P. H.; Kuchake, V. G.; Ingle, P. V.; Surana, S. J.; Dighore, P. N. // International Journal of PharmTech Research;Jan2009, Vol. 1 Issue 1, p50 

    The aim of the present study is to compare the effect of metformin in combination with Glimepiride and Glibenclamide In patient with type 2 Diabetes Mellitus. Subjects and method: This is an open-label, randomized study carried out to study the effect of metformin when it is given in combination...

  • Evaluation of Serum Zinc Status and Glycated Hemoglobin of Type 2 Diabetes Mellitus Patients in a Tertiary Care Hospital of Assam. Kumar Saharia, Gautom; Kanta Goswami, Rohini // Journal of Laboratory Physicians;Jan-Jun2013, Vol. 5 Issue 1, p30 

    The present study was undertaken to find out any correlation between serum zinc concentration and HbA1C% in patients with type 2 diabetes mellitus (DM). The study was carried out on 50 newly diagnosed patients of type 2 diabetes and controls in the Department of Biochemistry, Assam Medical...

  • Sitagliptin improved glycemic control and β-cell function in type 2 diabetes.  // ACP Journal Club;Mar/Apr2007, Vol. 146 Issue 2, p39 

    The article presents a study which states that sitagliptin improved glycemic control and ß-cell function in type 2 diabetes. In the study, 741 patients from 18 to 75 years of age who had type 2 diabetes mellitus with inadequate glycemic control on diet and exercise, had mean hemoglobin (Hb)...

  • Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control. Churdchomjan, Worachat; Kheolamai, Pakpoom; Manochantr, Sirikul; Tapanadechopone, Pirath; Tantrawatpan, Chairat; U-pratya, Yaowalak; Issaragrisil, Surapol // BMC Endocrine Disorders;2010, Vol. 10, p5 

    Background: Endothelial progenitor cells (EPCs) play an important role in vascular repair and a decrease in the number of EPCs is observed in type 2 diabetes. However, there is no report on the change of EPCs after glycemic control. This study therefore aimed to investigate the EPC number and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics