Effects of inhaled tumour necrosis factor alpha in subjects with mild asthma

Thomas, P.S.; Heywood, G.
September 2002
Thorax;Sep2002, Vol. 57 Issue 9, p774
Academic Journal
Background: The literature indicates that early exposure to children in the family and to day care permanently influences the development of allergic disease. A study was undertaken to examine the associations of family size and day care with adult asthma and hay fever and to determine whether these associations are mediated through specific IgE production and whether they vary with allergic predisposition. Methods: 18 530 subjects aged 20-44 years from 36 areas predominantly in the market economies participated in the European Community Respiratory Health Survey and provided information through interviewer-led questionnaires. 13 932 subjects gave blood samples for measurement of specific IgE. Results: Hay fever was less common in subjects with many siblings (OR=0.92; 95% CI 0.90 to 0.95 per sib). There was a U-shaped relationship between asthma and number of siblings (quadratic effect of siblings, pwheeze=0.014, pFEV[sub 1]=0.016). In subjects without siblings but exposed to children in day care, hay fever was less common (OR=0.76; 95% CI 0.60 to 0.98) and asthma symptoms were more common (ORwheeze=1.48; 95% CI 1.12 to 1.95). Adjustment for specific IgEs did not alter these associations. The inverse association of hay fever with siblings was found in sensitised subjects (OR=0.89; 95% CI 0.84 to 0.94) and in those with parental allergy (OR = 0.91; 95% CI 0.85 to 0.97), but not in subjects without such a predisposition (OR=1.02; 95% CI 0.97 to 1.09). Conclusion: Subjects exposed to many children at home or in day care experienced less hay fever and more asthma in adulthood. Microbial challenge through children may contribute to a non-allergic immunological development giving less hay fever but more airways infections predisposing to asthma. These effects were not mediated through production of specific IgE. The protective effect of siblings on hay fever was particularly strong in those with an allergic predisposition.


Related Articles

  • The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. Clayton, Robert A.; Dick, Colin A. J.; Mackenzie, Alison; Nagasawa, Michiaki; Galbraith, Deirdre; Hastings, Stuart F.; MacKenzie, Simon J. // Respiratory Research;2004, Vol. 5, p4 

    Background: The anti-inflammatory effects of the selective phosphodiesterase (PDE) inhibitors cilostazol (PDE 3), RO 20-1724 (PDE 4) and sildenafil (PDE 5) were examined in a murine model of allergic asthma. These compounds were used alone and in combination to determine any potential synergism,...

  • REACÅ¢IILE DE HIPERSENSIBILITATE SECUNDARE TERAPIEI CU ANTAGONIÅžTI TNFα - EXPERIENÅ¢A CLINICII DE REUMATOLOGIE CLUJ-NAPOCA. Manea, Irena; Pop, Oana Anamaria; Filipescu, Ileana; Cristea, Victor; Rednic, Simona // Clujul Medical;Dec2011, Vol. 84 Issue 4, p572 

    Objectives. Our aim was to evaluate the incidence of hypersensitivity adverse reactions secondary to immunomodulation therapy with TNFα antagonists (Infliximab) for patients with rheumatoid arthritis found in the registers of the Rheumatology Clinic between July 2000 and January 2011....

  • Role and Pharmacogenomics of TNF-α in Asthma. Lykouras, Dimosthenis; Sampsonas, Fotis; Kaparianos, Alexandros; Karkoulias, Kiriakos; Spiropoulos, Kostas // Mini Reviews in Medicinal Chemistry;Aug2008, Vol. 8 Issue 9, p934 

    Asthma is a chronic heterogeneous inflammatory disease of the respiratory system in which numerous cytokines play a significant role. Among them TNF-α (tumour necrosis factor α), a proinflammatory cytokine, has a predominant role in orchestrating airway inflammation and affecting treatment...

  • Tumour necrosis factor-α: The role of this multifunctional cytokine in asthma. Thomas, Paul S. // Immunology & Cell Biology;Apr2001, Vol. 79 Issue 2, p132 

    Analyzes the role of tumor necrosis factor (TNK)-alpha in the initiation of allergic asthmatic airway inflammation and the generation of airway hyper-reactivity. Cellular origin of TNF-alpha in asthmatic responses; Tumor necrosis factor receptors; Reduction in TNF-alpha activity.

  • Peripheral blood mononuclear cell production of TNF-a in response to North American ginseng stimulation. Zhou, David L.; Kitts, David D. // Canadian Journal of Physiology & Pharmacology;Oct2002, Vol. 80 Issue 10, p1030 

    North American ginseng (Panax quinquefolium) root extract (NAGE) with known ginsenosides composition was examined for its affinity to stimulate human tumour necrosis factor a (TNF-a) production in human peripheral blood mononuclear cells. Case studies were conducted in three donors, one that...

  • Allergy & immunology.  // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS3 

    Presents an abstract of the research manuscript `Treatment with IFN-gamma potentiates the release of TNF-alpha and MIP-1alpha during allergic reactions,' by E.Y. Bissonnette and R.E. Dery from the University of Alberta in Edmonton. Tumor necrosis factor (TNF); Interferon (IFN); Macrophage...

  • Inhaled corticosteroid effects both eosinophilic and non-eosinophilic inflammation in asthmatic patients. Basyigit, Ilknur; Yildiz, Fusun; Ozkara, Sevgiye Kacar; Boyaci, Hasim; Ilgazli, Ahmet // Mediators of Inflammation;Aug2004, Vol. 13 Issue 4, p285 

    A im To determine induced sputum cell counts and interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-a) and leukotriene B 4 (LTB 4 ) levels as markers of neutrophilic inflammation in moderate persistent asthma, and to evaluate the response to inhaled steroid therapy. Methods Forty-five...

  • The Soluble Tumor Necrosis Factor-Alpha Receptor Suppresses Airway Inflammation in a Murine Model of Acute Asthma. Hae-Seong Nam; Sook Young Lee; Seung Jun Kim; Ju Sang Kim; Soon Seog Kwon; Young Kyoon Kim; Kwan Hyung Kim; Hwa Sik Moon; Jeong Sup Song; Sung Hak Park; Seok Chan Kim // Yonsei Medical Journal;8/31/2009, Vol. 50 Issue 4, p569 

    Purpose: Tumor necrosis factor-alpha (TNF-α) is a proinflammatory cytokine that has been implicated in many aspects of the airway pathology in asthma. TNF-α blocking strategies are now being tried in asthma patients. This study investigated whether TNF-α blocking therapy inhibits airway...

  • Inhibition of Tumor Necrosis Factor α for Refractory Asthma. Erzurum, Serpil C. // New England Journal of Medicine;2/16/2006, Vol. 354 Issue 7, p754 

    The article presents the comments of the author on the treatment of refractory asthma with the soluble tumor necrosis factor (TNF) inhibitor etanercept. According to the author, the activation of TNF axis is a major cause of asthma. The author claims that the inhibition of TNF significantly...


Read the Article


Sign out of this library

Other Topics