TITLE

Formulation and Evaluation of Sustained Release Ambroxol Hydrochloride Microsphere Enriched Syrup

AUTHOR(S)
raja Kumar, Jaya
PUB. DATE
July 2014
SOURCE
Journal of Pharmaceutical Sciences & Research;2014, Vol. 6 Issue 7, p260
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The main objective of the present work is to formulate taste masked microspheres enriched syrup of ambroxol hydrochloride by an o/w emulsion solvent evaporation method. Such taste-masked formulations have been found to improve the quality of treatment in patients. Ambroxol hydrochloride microspheres help to protect the gastric mucous membrane from drug irritation and to mask its taste. The prepared microspheres enriched syrup were evaluated for particle size, effect of drug and polymer ration and volume of dispersed phase, percentage yield, incorporation efficiency, pH, viscosity, scanning electron microscopy and in vitro drug release. The microspheres produced exhibited good encapsulation efficiencies and rheological properties. The maximum percentage yield of microsphere is around 85.31%. The mean diameters of microspheres were found in range between 4μm to 14μm. The results of optimized formulations showed a narrow size distribution and smooth surface. In-vitro release showed 72.3% drug release after nine hours.
ACCESSION #
97816827

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics