TITLE

The Research of Ovarian Cancer with High Accuracy Continuous Circulation Intraperitoneal Hyperthermic Chemotherapy and Intravenous Chemotherapy

AUTHOR(S)
CUI Huan; ZHANG Ju-xin
PUB. DATE
February 2014
SOURCE
Journal of International Obstetrics & Gynecology;Feb2014, Vol. 41 Issue 1, p77
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Observe the clinical efficacy of the high accuracy continuous circulation intraperitoneal hyperthermic chemotherapy (IPHC) and intravenous chemotherapy for ovarian cancer. Methods; 50 patients of The People's Hospital of Zhengzhou University with satisfied ovarian cancer reductive surgery were divided into two groups: IPHC group, 28 patients with high accuracy continuous circulation intraperitoneal hyperthermic chemotherapy and intravenous chemotherapy; Control group, 22 patients with "paclitaxel liposome 135 mg/m² + oxaliplatin 135 mg/m²" (PT) intravenous chemotherapy, observed clinical treatment effect of two groups patients. Results: Compared the percentage of normal CA125 of two groups patients after 1 month, 3 months, the difference was statistically significant (all P<0.05). Two group patients one month, three months ascites treatment efficiency difference was statistically significant (P<0.05). Compared the grade II side effect of chemotherapy, IPHC group was lower than control group (χ² =7.417, P=0.006) ;and IPHC group's improvement rate of life quality was higher than control group's (χ² =5.936,P=0.015). Conclusions: High accuracy continuous circulation intraperitoneal hyperthermic chemotherapy and intravenous chemotherapy can improve the clinical efficacy of ovarian cancer, control of malignant ascites of ovarian cancer patients effectively, reduce side effects of chemotherapy and improve quality of life.
ACCESSION #
97776493

 

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