The Current Research of Thrombotic Thrombocytopenic Purpura in Pregnancy

WANG Tian -hong; CHENG Cheng; LI Ying-tao
February 2014
Journal of International Obstetrics & Gynecology;Feb2014, Vol. 41 Issue 1, p7
Academic Journal
Thrombotic thrombocytopenic purpura (TTP) is a rare life-threatening disorder. It is characterized by microan-giopathic hemolytic anemia, progressive thrombocytopenia, central nervous system disorder, fever and acute renal failure. It is caused by the absent or severe deficiency of the von Willebrand factor-cleaving protease named ADAMTS13. The pathogenesis of TTP is unknown, usually triggered after pregnancy. It causes maternal morbidity and fetal loss. Prompt aggressive management should include timely termination of pregnancy, plasma transfusion and/or plasma exchange.


Related Articles

  • Microangiopathic Hemolytic Anemia in Metastatic Carcinoma. Lohrmann, Hans-Peter; Adam, Wolfgang; Heymer, Berno // Annals of Internal Medicine;Sep73, Vol. 79 Issue 3, p368 

    Focuses on a study that observed eight patients with metastatic carcinoma and microangiopathic hemolytic anemia. Materials and methods; Results; Discussion.

  • Increased platelet retention in familial recurrent thrombotic thrombocytopenic purpura. Karpman, Diana; Holmberg, Lars; Jirgård, Lena; Lethagen, Stefan // Kidney International;Jan1996, Vol. 49 Issue 1, p190 

    We studied two brothers with recurrent thrombotic thrombocytopenic purpura (TTP). Platelet retention, measured with a modified Adeplat S glass-bead test, was found to be increased during acute episodes of TFP and during remissions. Values of platelet retention ranged between 57 to 95% (normal...

  • Severe limb necrosis: primary thrombotic microangiopathy or “seronegative” catastrophic antiphospholipid syndrome? A diagnostic dilemma. Lazurova, I.; Macejova, Z.; Tomkova, Z.; Remenar, F.; Boor, A.; Lazur, J.; Roland, R.; Rovensky, J.; Asherson, R. // Clinical Rheumatology;Oct2007, Vol. 26 Issue 10, p1737 

    An episode of gastroenteritis triggered severe necrosis of all extremities in a previously asymptomatic male. Hepatic and renal involvement were also manifest, while the hematological picture was one of thrombotic microangiopathic hemolytic anemia. Antiphospholipid antibodies were negative. He...

  • TTP/HUS: observational studies generate hypotheses that lead to randomized controlled trials. Clark, William F.; Forzley, Brian R.; Sontrop, Jessica M.; Kadri, Albert; Moist, Louise M.; Suri, Rita S.; Salvadori, Marina S.; Garg, Amit X. // Kidney International Supplement;Feb2009, Issue 112, pS50 

    Thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) is a disease syndrome, and its history exemplifies how small observational studies lead to hypotheses that spawn randomized control trials (RCTs). Moschowitz's original case report coupled with the case findings of...

  • Thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS): treatment outcome, relapses, prognostic factors. A single-center experience of 48 cases. Dervenoulas, J.; Tsirigotis, P.; Bollas, G.; Pappa, V.; Xiros, N.; Economopoulos, T.; Pappa, M.; Mellou, S.; Kostourou, A.; Papageorgiou, E.; Raptis, S. A. // Annals of Hematology;Feb2000, Vol. 79 Issue 2, p66 

    The thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS) is a rare disorder characterized by microangiopathic hemolysis and thrombocytopenia. We have undertaken a retrospective analysis of the clinical characteristics, treatment outcome, and prognosis of 48 patients diagnosed...

  • Mechanisms of microvascular thrombosis in thrombotic thrombocytopenic purpura. Han-Mou Tsai // Kidney International Supplement;Feb2009, Issue 112, pS11 

    Recent studies have demonstrated that thrombotic thrombocytopenic purpura (TTP), a serious thrombotic disorder affecting the arterioles and capillaries of multiple organs, is caused by a profound deficiency in the von Willebrand factor cleaving metalloprotease, ADAMTS13. ADAMTS13, a 190-kD...

  • Vincristine as treatment for recurrent episodes of thrombotic thrombocytopenic purpura. Ferrara, F.; Annunziata, M.; Pollio, F.; Palmieri, S.; Copia, C.; Mele, G.; Pocali, B.; Schiavone, E. M. // Annals of Hematology;Jan2002, Vol. 81 Issue 1, p7 

    The clinical course of thrombotic thrombocytopenic purpura has dramatically improved after the introduction of plasma-based therapy, including plasma exchange and plasma infusion. However, a considerable number of patients still experience relapse after initial successful treatment. In this...

  • Postpartum Thrombotic Thrombocytopenic Purpura (TTP) Complicating Pregnancy-associated Immune Thrombocytopenic Purpura (ITP). Olenich, Martee; Schattner, Elaine // Annals of Internal Medicine;5/15/94, Vol. 120 Issue 10, p845 

    Presents a case report on a young pregnant woman with refractory immune thrombocytopenic purpura who developed postpartum thrombotic thrombocytopenic purpura. Medical record of the patient; Results and discussion.

  • THROMBOTIC THROMBOCYTOPENIC PURPURA OCCURRING IN THE PUERPE RIUM. Eisenstadt, H. B. // American Journal of Gastroenterology;Nov1959, Vol. 32 Issue 5, p651 

    Presents an abstract of the study "Thrombotic Thrombocytopenic Purpura Occurring in the Puerperium," by Harold N. Harrison, published in the July 1958 issue of the "Archives of Internal Medicine."


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics