TITLE

Expression and Significance of Twist2 and E-cadherin in Cervical Squamous Cell Carcinoma

AUTHOR(S)
GE Yon; YANG Yong-xiu; HU Le; LIU Chang; ZHU Jun
PUB. DATE
February 2014
SOURCE
Journal of International Obstetrics & Gynecology;Feb2014, Vol. 41 Issue 1, p63
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Study Twist2 and E-cadherin expression in cervical intraepithelial neoplasia and cervical squamous cell carcinoma,and explore their roles and significance in the process of cervical cancer. Methods; Using western blot (Western blot) and immunohistochemistry method to detecte Twist2, E-cadherin expression in normal cervical tissue (control group),group CIN I, CIN II-III group, cervical squamous cell carcinoma. Results; The differences of the positive expression rate of Twist2 and E-cadherin in four groups were statistically significant (χ² = 48.163, P = 0.000; χ² = 43.169, P=0.000). The positive expression rate of Twist2, E-cadherin in cervical squamous cell differentiation, clinical stage, lymph node metastasis between the groups, the difference was statistically significant (P<0.05),no statistically significant difference between the different age groups (P>0.05). Twist2 and E-cadherin expression was negatively correlated (r=-0.401, P=0.003) in cervical squamous cell carcinoma. Control group, CIN group, cervical squamous cell carcinoma relative expression levels of Twist2, E-cadherin difference was statistically significant (F=652.225, P=0.000; F=299.112, P=0.000). Conclusions: Twist2, E-cadherin may participate in the process of malignant transformation of cervical squamous cell carcinoma, joint detection Twist2, E-cadherin help to determine the degree of malignancy of cervical cancer and its prognosis.
ACCESSION #
97776484

 

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