Effects of Male Factors on Outcomes of Intrauterine Insemination

SU Ning; XIA Wei; WANG Wei; HE Yan; ZENG Yon -hua; HUANG Ting-ting; PENG Ya-ya
March 2014
Journal of International Reproductive Health/Family Planning;Mar2014, Vol. 33 Issue 2, p110
Academic Journal
Objective: To assess the effects of male factors on the clinical pregnancy rate of intrauterine insemination (IUI). Methods: The data of 472 IUI cycles from January 2012 to April 2013 in our center were retrospectively analyzed. These cycles were divided into three groups according to male age (<30, 30~35, ≥35 years), four groups according to the percentage of normal morphological spermatozoa (normal: ≥15% ;mild, moderate and severe abnormal: 10%-15%, 5%-10%, ≤4%), or five groups according to the processed total motile sperm count (PTMS) (<2 x 106, (2-5) x 106, (5-10) x 106, (10-20) x 106, ≥ 20 x 106). Then the clinical pregnancy rates were compared. Results: A total of 80 clinical pregnancies were obtained, for a pregnancy rate per cycle of 16.95% and accumulative rate 33.47%. The clinical pregnancy rate in the ≥35 years old group was 10.4%, in severe abnormal group was 8.4%. These rates were significantly lower than those of other groups (P <0.05). Conclusions: Male factors such as age, the percentage of normal morphological spermatozoa, and PTMS should be considered during IUI therapy. Those couples with male age ≥35 years, severe abnormal spermatozoa, or PTMS <2 x 106, should be advised to treat with IVF-ET or ICSI-ET.


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