TITLE

Protective Effect of Nigella Sativa Against Diabetic Complications on The Liver in White Male Rats

AUTHOR(S)
Abdellatif, Nassar Ayoub
PUB. DATE
October 2013
SOURCE
Egyptian Journal of Hospital Medicine;Oct2013, Vol. 53, p1072
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim of the work: The effect of diabetes on the liver is associated with histological changes. The aim of the present study was to evaluate the histological changes following administration of nigella sativa (NS) in the streptozotocin (STZ) induced diabetes mellitus in rats. Materials and Methods: Thirty six male white rats (n=36), weighing (180-230 g) were taken for this study. The animals were divided into 3 groups: 1- Normal control group. 2- Diabetic group. 3- Diabetic group treated by Nigella Sativa (N.S) oil. Diabetes was induced in the experimental rats via intraperitoneal injection of streptozotocin (45 mg/kg body weight) in a single dose. The fasting blood glucose was estimated, 5ml\kg of body weight of N. sativa oil was given orally for three weeks. After an overnight fast, the animals were sacrificed. The livers were identified, weighed and observed for any gross appearance and color changes and tissues were preserved for histopathological studies using hematoxylin & eosin (H&E) and periodic acid Schiff (PAS) stains. Results: In streptozotocin treated animals, the body weight was significantly decreased compared to normal rats, while treating diabetic rats with N. sativa oil showed significant increases in the body weight. Administration of nigella sativa oil to diabetic rats resulted in a significant decrease in blood glucose after three weeks compared to untreated diabetic rats. In untreated diabetic group, there was a significant decrease in the liver glycogen. Light microscopic examination of the liver of diabetic rats revealed profound histological changes. Nigella sativa consumption could reverse most of these histological and biochemical changes in the liver of the diabetic group owing to its hypoglycemic and antioxidant effect. Conclusion: The Nigella Sativa due to its antioxidant role may be helpful in reversing the changes in the liver in diabetes mellitus.
ACCESSION #
97745985

 

Related Articles

  • Hyperbaric Oxygen Therapy to Treat Diabetes Impaired Wound Healing in Rats. Tuk, Bastiaan; Tong, Miao; Fijneman, Esther M. G.; van Neck, Johan W. // PLoS ONE;Oct2014, Vol. 9 Issue 10, p1 

    Wound healing in diabetes is frequently impaired and its treatment remains a challenge. Hyperbaric oxygen therapy (HBOT) receives a wide attendance and is often used as a last resort treatment option, however, its effectiveness for many conditions is unproven. We tested the effect of HBOT on...

  • Diabetes mellitus and renal involvement in chronic viral liver disease. V. F., lovanescu; C. T., Streba; M., lonescu; A. F., Constantinescu; C. C., Vere; I., Rogoveanu; E., Moţa // Journal of Medicine & Life;Oct-Dec2015, Vol. 8 Issue 4, p483 

    Hypothesis: Chronic viral liver disease is often associated with other conditions. Diabetes mellitus (DM) is frequently reported in this context and may play a role in the progression of the liver disease to hepatocellular carcinoma (HCC). Renal disease is also an important extrahepatic...

  • Impaired Elastic Properties of the Aorta in Fat-Fed, Streptozotocin-Treated Rats. Sun, Hui; Zhong, Ming; Miao, Ya; Ma, Xiao; Gong, Hui-Ping; Tan, Hong-Wei; Zhang, Yun; Zhang, Wei // Cardiology;2009, Vol. 114 Issue 2, p107 

    Background: Vascular complications associated with diabetes are the major cause for the increased morbidity and mortality in diabetic patients. However, the progression of vascular complications in diabetes is not well understood. We aimed to investigate the biomechanical and biochemical changes...

  • The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats. Erion, Derek M.; Lapworth, Amanda; Amor, Paul A.; Bai, Guoyun; Vera, Nicholas B.; Clark, Ronald W.; Yan, Qingyun; Zhu, Yimin; Ross, Trenton T.; Purkal, Julie; Gorgoglione, Matthew; Zhang, Guodong; Bonato, Vinicius; Baker, Levenia; Barucci, Nicole; D’Aquila, Theresa; Robertson, Alan; Aiello, Robert J.; Yan, Jiangli; Trimmer, Jeff // PLoS ONE;May2014, Vol. 9 Issue 5, p1 

    Hyperglycemia resulting from type 2 diabetes mellitus (T2DM) is the main cause of diabetic complications such as retinopathy and neuropathy. A reduction in hyperglycemia has been shown to prevent these associated complications supporting the importance of glucose control. Glucokinase converts...

  • The effects of regular aerobic exercise on renal functions in streptozotocin induced diabetic rats. Kurdak, Hatice; Sandikçi, Sunay; Ergen, Nilay; Dogan, Ayse; Kurdak, Sanli Sadi // Journal of Sports Science & Medicine;Jun2010, Vol. 9 Issue 2, p294 

    Diabetic nephropathy is a feared complication of diabetes since it can lead to end-stage renal failure and also it is a risk factor of cardiovascular disease. The important clinical problems caused by diabetic nephropathy are proteinuria and decreased renal function. Exercise is a cornerstone of...

  • Pancreatic Kininogenase Ameliorates Renal Fibrosis in Streptozotocin Induced-Diabetic Nephropathy Rat. Zhu, Dan; Zhang, Linlin; Cheng, Lijuan; Ren, Liansheng; Tang, Jie; Sun, Dianjun // Kidney & Blood Pressure Research;Feb2016, Vol. 41 Issue 1, p9 

    Background/Aims: We aimed to evaluate whether pancreatic kininogenase (PKase) can relieve renal fibrosis and investigate its mechanisms in diabetic nephropathy (DN) rats Methods: We established streptozotocin (STZ) induced-DN rats. After treatment with PKase for 4 weeks, urinary weight, urinary...

  • Aldosterone Antagonists in Monotherapy Are Protective against Streptozotocin-Induced Diabetic Nephropathy in Rats. Banki, Nora F.; Ver, Agota; Wagner, Laszlo J.; Vannay, Adam; Degrell, Peter; Prokai, Agnes; Gellai, Renata; Lenart, Lilla; Szakal, Dorottya-Nagy; Kenesei, Eva; Rosta, Klara; Reusz, Gyorgy; Szabo, Attila J.; Tulassay, Tivadar; Baylis, Chris; Fekete, Andrea // PLoS ONE;Jun2012, Vol. 7 Issue 6, p1 

    Angiotensin converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARB) are the standard clinical therapy of diabetic nephropathy (DN), while aldosterone antagonists are only used as adjuncts. Previously in experimental DN we showed that Na/K ATPase (NKA) is mislocated and...

  • Antioxidant and Antidiabetic Effect of Aqueous Fruit Extract of Juss. on Streptozotocin Passiflora ligularis Induced Diabetic Rats. Anusooriya, Palanirajan; Malarvizhi, Deivasigamani; Gopalakrishnan, Velliyur Kanniappan; Devaki, Kanakasabapathi // ISRN Otolaryngology;2014, p1 

    Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostasis resulting in severe diabetic complications including retinopathy, angiopathy, nephropathy, and neuropathy causing neurological disorders due to perturbation in utilization of glucose. Hypoglycemic activity...

  • N-Acetylcysteine and Allopurinol Synergistically Enhance Cardiac Adiponectin Content and Reduce Myocardial Reperfusion Injury in Diabetic Rats. Wang, Tingting; Qiao, Shigang; Lei, Shaoqing; Liu, Yanan; Ng, Kwok F. J.; Xu, Aimin; Lam, Karen S. L.; Irwin, Michael G.; Xia, Zhengyuan // PLoS ONE;2011, Vol. 6 Issue 8, p1 

    Background: Hyperglycemia-induced oxidative stress plays a central role in the development of diabetic myocardial complications. Adiponectin (APN), an adipokine with anti-diabetic and anti-ischemic effects, is decreased in diabetes. It is unknown whether or not antioxidant treatment with...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics