Contributions of Insulin-Resistance and Insulin-Secretory Defects to the Pathogenesis of Type 2 Diabetes Mellitus

Gerich, John E.
April 2003
Mayo Clinic Proceedings;Apr2003, Vol. 78 Issue 4, p447
Academic Journal
Examines the role of insulin resistance and insulin-secretory defects in the pathogenesis of type-2 diabetes mellitus. Genetic factors involved in the alteration of insulin sensitivity and impairment of beta-cell function; Importance of optimal glycemic control in the management of diabetes; Factors regulating glucose homeostasis.


Related Articles

  • Insulin Secretion: Movement at All Levels. Henquin, Jean-Claude; Boitard, Christian; Efendic, Suad; Ferrannini, Ele; Steiner, Donald F.; Cerasi, Erol // Diabetes;Feb2002 Supplement, Vol. 51, pS1 

    Editorial. Examines the effects of insulin resistance on type two diabetes. Increase of cytosolic beta-cells; Decrease of hyperglycemia; Release of the glucose metabolism.

  • Accurate Assessment of β-Cells Function. Bergman, Richard N.; Ader, Marilyn; Huecking, Katrin; Van Citters, Gregg // Diabetes;Feb2002 Supplement, Vol. 51, pS212 

    Only in the last decade did modeling studies predict, and knockout experiments confirm, that type 2 diabetes is a “2-hit” disease in which insulin resistance is necessarily accompanied by β-cell defect(s) preventing the compensatory upregulation of insulin secretion. This...

  • A Model to Explore the Interaction Between Muscle Insulin Resistance and beta-Cell Dysfunction... Mauvais-Jarvis, Franck; Virkamaki, Antti; Michael, M. Dodson; Winnay, Jonathon N.; Zisman, Ariel; Kulkarni, Rohit N.; Kahn, C. Ronald // Diabetes;Dec2000, Vol. 49 Issue 12, p2126 

    Explores the interaction between muscle insulin resistance and beta-cell dysfunction in type 2 diabetes. Comparison between glucose tolerance of the two groups of mice; Effects of insulin resistance on beta-cell insulin secretion; Involvement of muscles on insulin regulation.

  • Angiotensin II in Type 2 Diabetes Mellitus. Kwan Yi Chu; Po Sing Leung // Current Protein & Peptide Science;Feb2009, Vol. 10 Issue 1, p75 

    Angiotensin II (Ang II) is well-known as a systemic vasoconstrictor but recently a novel role for the peptide in endocrine function has been suggested and it has been linked to the pathophysiology of type 2 diabetes mellitus. According to several large-scale clinical studies, blocking Ang II...

  • Is Intestinal Gluconeogenesis a Key Factor in the Early Changes in Glucose Homeostasis Following Gastric Bypass? Hayes, Mark Thomas; Foo, Jonathan; Besic, Vinko; Tychinskaya, Yulia; Stubbs, Richard Strawson // Obesity Surgery;Jun2011, Vol. 21 Issue 6, p759 

    Background: In 2008, Troy et al. hypothesised that under fasting conditions, intestinal gluconeogenesis generates glucose levels in the portal vein which trigger the portal sensor to change insulin resistance and that this mechanism contributes to the effects of Roux-en-Y gastric bypass (RYGB)...

  • Components of Metabolic Syndrome Predicting Diabetes: No Role of Inflammation or Dyslipidemia. Norberg, Margareta; Stenlund, Hans; Lindahl, Bernt; Andersson, Christer; Weinehall, Lars; Hallmans, Garan; Eriksson, Jan W. // Obesity (19307381);Jul2007, Vol. 15 Issue 7, p1875 

    The article discusses the results of a study on the structure of metabolic syndrome (MetSy) and its components for prediction of type 2 diabetes. It states that inflammation and dyslipidemia factors were not independently related with the risk of diabetes. It says that the core perturbations...

  • Use of Homeostatic Model Assessment in Managing Type 2 Diabetes. Kadić, Damira; Dautbegović-Stevanović, Davorka // Folia Medica Facultatis Medicinae Universitatis Saraeviensis;2011, Vol. 46 Issue 1, p48 

    The prevalence of type 2 diabetes has reached epidemic proportions worldwide, and the incidence of the life-threatening complications of diabetes is increasing. It is of great importance to make a good assessment of newly diagnosed diabetics and to select an appropriate treatment. Without the...

  • Stemming the Tide of Type 2 Diabetes: Bring on the “Big Guns”. Buchanan, Thomas A. // Obesity (19307381);Jun2010, Vol. 18 Issue 6, p1065 

    The author proposes a solution on how to reduce the risk of type 2 diabetes in high-risk individuals in developing and developed countries. He references findings from clinical trials conducted since 2000. He elaborates the lessons that can be learned from the types of interventions studied,...

  • The Relationship between Serum Ghrelin with Beta-Cell Function Index and Insulin Resistance in People with Type 2 Diabetes. Izadi, Mojtaba; Soheli, Shahram; Khorshidi, Davoud; Doali, Hossein // Journal of Mazandaran University of Medical Sciences (JMUMS);Jun/Jul2011, Vol. 21 Issue 82, p18 

    Background and purpose: Considerable attention has recently been paid to the role of ghrelin hormone in the metabolism of carbohydrate. Beta-cell dysfunction is also considered to be an important factor in the prevalence of diabetes. This study aimed at investigating the relationship between...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics