Different hepatitis B virus core gene mutations in children with chronic infection and hepatocellular carcinoma

Ni, Y.-H.; Chang, M.-H.; Hsu, H.-Y.; Tsuei, D.-J.
January 2003
Gut;Jan2003, Vol. 52 Issue 1, p122
Academic Journal
Background: The significance of mutations of hepatitis B virus (HBV) precore/core antigen in causing persistent infection and subsequent liver diseases is debatable. Aim: To investigate HBV core gene sequence changes in children with chronic HBV infection and their implications in hepatocellular carcinoma (HCC). Methods: Thirty one chronic HBV infected children with documented hepatitis B e antigen seroconversion selected from 415 long term carrier children and 12 HBV related HCC children were studied. Four serial serum samples before and after hepatitis B e antigen seroconversion from each of the 31 children, and one serum sample taken from the 12 HCC children were subjected to HBV core gene sequence analysis. Results: Mutations accumulated as chronic infection persisted and most frequently occurred at core gene codon 21 (29%), codon 147 (29%), codon 65 (16%), and precore stop codon 28 (74%) in the 31 chronic HBV infected children. Core gene mutation sites in HCC children were identified at core codons 74, 87, and 159. HCC children had more mutations in the core gene than those with chronic HBV infection (p=0.013). Conclusion: Accumulation of mutations of HBV core region in HCC children differ from those in chronic HBV infected children. This may be a clue to the pathogenesis of paediatric HCC.


Related Articles

  • Hepatitis B virus X protein: a multifunctional viral regulator. Murakami, Seishi // Journal of Gastroenterology;2001, Vol. 36 Issue 10, p651 

    Hepatitis B Virus (HBV) infection is one of the major causes of hepatocellular carcinoma (HCC). X protein (HBx) has been suspected to be oncogenic, although the precise role(s) remain uncertain. HBx is a multifunctional viral regulator that modulates transcription, cell responses to genotoxic...

  • Hepatocellular Carcinoma. Di Bisceglie, Adrian M.; Rustgi, Vinod K.; Hoofnagle, Jay H.; Dusheiko, Geoffrey M.; Lotze, Michael T. // Annals of Internal Medicine;Mar88, Vol. 108 Issue 3, p390 

    Focuses on hepatocellular carcinoma. Nature of hepatocellular carcinoma; Role of hepatitis B virus infection in the etiology of hepatocellular carcinoma; Epidemiology of hepatocellular carcinoma; Diagnosis and treatment of hepatocellular carcinoma.

  • Hepatitis B Virus Genotype and Mutants: Risk Factors for Hepatocellular Carcinoma. Llovet, Josep M.; Lok, Anna // JNCI: Journal of the National Cancer Institute;8/20/2008, Vol. 100 Issue 16, p1121 

    The article discusses various topics published within the issue, including one on the examination of the risk of hepatocellular carcinoma (HCC) associated with hepatitis B virus (HBV) genotypes and the analysis on the risk factors for cancer with age older than 60 years old.

  • Editorial. Okita, Kiwamu // Journal of Gastroenterology;1998, Vol. 33 Issue 4, p604 

    Editorial. Comments on the detection of serum hepatitis B,C, and D viral nucleic acids and its implications in hepatocellular carcinoma. Role of hepatitis virus B in liver carcinogenesis; Discussion of hepatocarcinogenesis in humans.

  • Association of hepatitis viruses with hepatocellular carcinoma in Thailand. Tangkijvanich, Pisit; Hirsch, Petra; Theamboonlers, Apiradee; Nuchprayoon, Issarang; Poovorawan, Yong // Journal of Gastroenterology;1999, Vol. 34 Issue 2, p227 

    Abstract: Hepatocellular carcinoma (HCC) represents the most common form of malignant tumor among males in Thailand, an area endemic for hepatitis B virus (HBV) infection. Various risk factors have been associated with the development of HCC, among them exposure to certain toxins, and infection...

  • Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses. Sitterlin, Delphine; Bergametti, Fran├žoise; Tiollais, Pierre; Tennant, Bud C; Transy, Catherine // Oncogene;9/7/2000, Vol. 19 Issue 38, p4427 

    A fully effective treatment of chronic human hepatitis B virus (HBV) infection is still missing and HBV remains the first etiological agent of liver cancer. Although the viral regulatory X protein is essential for infection, its mode of action remains obscure, due the lack of an in vitro...

  • Distinctive gene expression profiles associated with Hepatitis B virus x protein. Wu, Chuan-Ging; Salvay, David M; Forgues, Marshonna; Valerie, Kristoffer; Farnsworth, Julie; Markin, Rodney S; Wang, Xin Wei // Oncogene;6/21/2001, Vol. 20 Issue 28, p3674 

    Hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). HBV encodes the potentially oncogenic HBx protein, which mainly functions as a transcriptional co-activator involving in multiple gene deregulations. However, mechanisms underlying HBx-mediated...

  • Expression profile of nine novel genes differentially expressed in hepatitis B virus-associated hepatocellular carcinomas. Kim, Mi-Young; Park, Eun; Park, Jung-Hyang; Park, Dong-Hyun; Moon, Woo-Sung; Cho, Back-Hwan; Shin, Hee-Sup; Kim, Dae-Ghon // Oncogene;7/27/2001, Vol. 20 Issue 33, p4568 

    Chronic hepatitis B virus (HBV) infection is known to be one of the major causes in the development of hepatocellular carcinoma (HCC), although the biomolecular mechanism(s) involved remain unclear. To identify the cellular gene(s) involved in HBV-associated hepatocarcinogenesis, we used the...

  • Hepatitis C Virus Infection and the Rising Incidence of Hepatocellular Carcinoma. Harnois, Denise M. // Mayo Clinic Proceedings;Jan2012, Vol. 87 Issue 1, p7 

    An introduction is presented in which the editor discusses various reports within the issue on topics including the incidence and etiologic trend of hepatocellular carcinoma (HCC) among patient populations in Minnesota and Hepatitis B virus (HBV) affecting Somalis.


Read the Article


Sign out of this library

Other Topics