Tachykinins potently stimulate human small bowel blood flow: a laser Doppler flowmetry study in humans
- Tachykinins: Role in Human Gastrointestinal Tract Physiology and Pathology. Improta, Giovanna; Broccardo, Maria // Current Drug Targets;Aug2006, Vol. 7 Issue 8, p1021
Tachykinins (TKs) and their receptors (NK1, NK2 and NK3), which are diffusely expressed in the human gastrointestinal tract, represent an endogenous modulator system regulating enteric secretomotor functions, inflammatory and immune responses, and visceral hypersensitivity, mainly during...
- Anti-tumour activity of tachykinin NK1receptor antagonists on human glioma U373 MG xenograft. Palma, C; Bigioni, M; Irrissuto, C; Nardelli, F; Maggi, C A; Manzini, S // British Journal of Cancer;1/15/2000, Vol. 82 Issue 2, p480
Astrocytes harbour functional receptors to many neurotransmitters, including substance P (SP), an undecapeptide belonging to the tachykinin family of peptide transmitters. SP activates malignant glial cells to induce cytokine release and proliferation, both responses being relevant for tumour...
- Involvement of Tachykinins in Endotoxin-Induced Airway Hyperresponsiveness. Loeffler, B.S.; Arden, W.A.; Fiscus, R.R.; Lee, L.-Y. // Lung;1997, Vol. 175 Issue 4, p253
Inhaled endotoxin, lipopolysaccharide (LPS), has been shown to result in bronchial hyperresponsiveness (BHR) to endogenous bronchoconstrictive mediators such as histamine. To determine the role of sensory neuropeptides released from bronchopulmonary C-fibers in LPS-induced BHR, 24 guinea pigs...
- PreBÃ¶tzinger complex (preBÃ¶tC) neurokinin-1 receptor (NK1R) expressing neurons are required for eupnea in adult awake rats. Gray, P. A.; Janczewski, W. A.; Mellen, N.; McCrimmon, D. R.; Feldman, J. L. // Respiratory Research;2001 Supplement 1, Vol. 2, pS7
An abstract of the study "PreBÃ¶tzinger complex (preBÃ¶tC) neurokinin-1 receptor (NK1R) expressing neurons are required for eupnea in adult awake rats," by P.A. Gray and colleagues is presented.
- An FDA Approved Neurokinin-1 Receptor Antagonist is Effective in Reducing Intraabdominal Adhesions when Administered Intraperitoneally, But Not Orally. Lim, Rizal; Morrill, Jonathan M.; Prushik, Scott G.; Reed, Karen L.; Gower, Adam C.; Leeman, Susan E.; Stucchi, Arthur F.; Becker, James M. // Journal of Gastrointestinal Surgery;Jan2009, Vol. 13 Issue 1, p43
A correction to the article "An FDA Approved Neurokinin-1 Receptor Antagonist is Effective in Reducing Intraabdominal Adhesions When Administered Intraperitoneally, But Not Orally," by R. Lim et al. which appeared in a previous issue is presented.
- Neurokinin A. // Encyclopedic Reference of Molecular Pharmacology;2004, p632
An encyclopedia entry for "neurokinin A" is presented.
- Substance K. // Encyclopedic Reference of Molecular Pharmacology;2004, p890
An encyclopedia entry for Substance K is presented.
- Did you know... // Tufts University Health & Nutrition Letter;May98, Vol. 16 Issue 3, p8
Reveals the gastrointestinal tract's measurement if it were stretched straight.
- Laxatives rarely needed. Cummings, M. // FDA Consumer;Apr91, Vol. 25 Issue 3, p33
Reports that laxatives can pose the risk of side effects and habituation. Avoiding quick fix laxatives; Description of several laxatives and how they work; Lifestyle changes to alleviate constipation; Adverse effects. INSET: Types of laxatives..