Ablative mucosectomy is the procedure of choice to prevent Barrett's cancer

Fitzgerald, R.C.
January 2003
Gut;Jan2003, Vol. 52 Issue 1, p16
Academic Journal
Focuses on the role of ablative therapies as a cancer preventive strategy in Barrett's esophagus patients without high grade dysplasia. Issue whether all of the specialized intestinal metaplasia can be eradicated from the esophagus so that the risk can be eliminated without the requirement for continued surveillance; Promise of chemoprevention as cancer prevention strategies.


Related Articles

  • Esophageal inlet patch. Belafsky, Peter C.; Postma, Gregory N.; Koufman, James A. // ENT: Ear, Nose & Throat Journal;Jan2002, Vol. 81 Issue 1, p18 

    Presents information on esophageal inlet patch. Comparison of the inlet patch to Barrett's metaplasia of the distal esophagus.

  • Magnification chromoendoscopy for the detection of intestinal metaplasia and dysplasia in Barrett's oesophagus. Sharma, P.; Weston, A.P.; Topalovski, M.; Cherian, R.; Bhattacharyya, A.; Sampliner, R.E. // Gut;Jan2003, Vol. 52 Issue 1, p24 

    Background: The presence of intestinal metaplasia (IM) in the columnar lined distal oesophagus defines Barrett's oesophagus with the risk of future malignant transformation. The distribution of both IM and dysplasia (Iow grade (LGD) and high grade (HGD)) within the columnar lined oesophagus is...

  • Is Barrett's Esophagus Associated with Intestinal Metaplasia of the Gastric Cardia? Morales, Thomas G.; Bhattacharyya, Achyut; Johnson, Cynthia; Sampliner, Richard E. // American Journal of Gastroenterology;Oct1997, Vol. 92 Issue 10, p1818 

    Objective: Barrett's esophagus has been associated with adenocarcinoma of the esophagogastric junction and gastric cardia. The purpose of this study was to determine whether patients with Barrett's esophagus have a higher prevalence of intestinal metaplasia involving the gastric cardia than...

  • Short Segment Barrett's Esophagus: Relationship of Age With Extent of Intestinal Metaplasia. Benipal, Paramjit; Garewal, Harinder S.; Sampliner, Richard E.; Martinez, Patricia; Hayden, Craig W.; Fass, Ronnie // American Journal of Gastroenterology;Nov2001, Vol. 96 Issue 11, p3084 

    OBJECTIVE: Short segment Barrett's esophagus (SSBE) is defined by the presence of intestinal metaplasia in biopsies obtained from mucosa with an appearance suggestive of Barrett's that extends <3 cm into the esophagus. It has been suggested that this lesion may represent a stage in an on-going...

  • Tongue-like Barrett's esophagus is associated with gastroesophageal reflux disease. Yamagishi, Hatsushi; Koike, Tomoyuki; Ohara, Shuichi; Kobayashi, Shigeyuki; Ariizumi, Ken; Abe, Yasuhiko; Iijima, Katsunori; Imatani, Akira; Inomata, Yoshifumi; Kato, Katsuaki; Shibuya, Daisuke; Aida, Shigemitsu; Shimosegawa, Tooru // World Journal of Gastroenterology;7/14/2008, Vol. 14 Issue 26, p4196 

    AIM: To test this hypothesis of barrett esophagus (BE) classified into two types and to further determine if there was any correlation between the shape of endoscopically suspected esophageal metaplasia (ESEM), prevalence of reflux esophagitis (RE) and heartburn. METHODS: A total of 6504...

  • Barrett's Esophagus after Cardiomyotomy for Esophageal Achalasia. Jaakkoia, Ari; Reinikainen, Pekka; Ovaska, Jari; Isolauri, Jouko // American Journal of Gastroenterology;Feb1994, Vol. 89 Issue 2, p165 

    Heller's myotomy for esophageal achalasia was performed on 64 patients in the 24 yr up to 1988. After follow-up averaging 13 yr, 46 patients were reexamined with endoscopy, biopsy, and manometry. Barrett's metaplasia of the distal esophagus was found in four patients 6, 13, 20, and 23 yr after...

  • DYSREGULATION OF THE MAJOR SQUAMOUS CELL STRESS RESPONSIVE SYSTEM IN BARRETT'S METAPLASIA. Dolziel, H.H.; Pohler, E.; Craig, A.L.; Kernohan, N.; Hopwood, D.; Dillon, J.F.; Hupp, T.R. // Gut;Apr2003 Supplement 1, Vol. 52, pA7 

    The epithelial cells of the oesophagus are routinely exposed to unique environmental pressures, including thermal stress, acid and bile reflux, and dietary carcinogens, which appear to play a role in development of metaplasia, increased selection pressure for early mutation of p53, and therefore...

  • THE IDENTIFICATION OF P53 MUTATIONS IN METAPLASTIC BARRETT'S TISSUES: A PROGNOSTIC MARKER? Jenkins, G.J.S.; Doak, S.H.; Griffiths, A.P.; Parry, J.M.; Baxter, J.N. // Gut;Apr2003 Supplement 1, Vol. 52, pA57 

    We have analysed multiple biopsies from over 40 Barrett's patients with a range of pre-malignant conditions, for the presence of p53 mutations. We have employed a molecular technique, the Restriction Site Mutation (RSM) assay to detect the presence of Iow-frequency p53 mutations. The advantage...

  • The Incidence of Adenocarcinoma and Dysplasia in Barrett's Esophagus. O'Connor, J. Barry; Falk, Gary W.; Richter, Joel E. // American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2037 

    OBJECTIVE: The reported incidence of adenocarcinoma in Barren's esophagus is variable. The aim of this study was to determine the incidence of dysplasia and adenocarcinoma in a population of patients with Barrett's esophagus followed prospectively and to compare these findings with other series....


Read the Article


Sign out of this library

Other Topics