Badreldin, R.; Ramakrishnan, S.; Ellis, W.R.; Maklon, A.F.; Yiannakou, J.Y.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA111
Academic Journal
Introduction and Aims: The Olympus XQ240Z endoscope allows x100 magnification of the mucosal surface. Accurate detection of villous atrophy (VA) could allow all patients attending for endoscopy to be screened for coeliac disease. The aim of this study was to assess whether interpretation of zoom endoscopy images is an easily transferable skill. Methodology: Four endoscopists with either little or no experience of zoom endoscopy were asked to view 246 'zoom' images of duodenal mucosa to identify VA. The images where obtained by endoscopist RB who is experienced in zoom endoscopy (400 procedures), and who was aware of clinical details. Reasonable quality single images were selected, 227 of which were normal and 20 with VA. A further 20 images, 10 each showing normal villi and VA were selected for a brief 10 minute practice session before the exercise. Results: RB's sensitivity in identifying VA is 100% with a specificity of 99.1%. Results of the four endoscopists assessing images are shown in the Table. Conclusion: Zoom endoscopy is likely to be an effective method for detecting coeliac disease. These figures show that even with minil mai training, and under adverse conditions (ie single image), recognition of villous atrophy on zoom endoscopy is an easily transferable skill. A large scale study is under way to assess the efficacy of zoom endoscopy in screening for coeliac disease in patients attending for direct access endoscopy.


Related Articles

  • The insensitivity of endoscopic markers in celiac disease. Oxentenko, Amy S.; Grisolano, Scott W.; Murray, Joseph A.; Burgart, Lawrence J.; Dierkhising, Ross A.; Alexander, Jeffrey A. // American Journal of Gastroenterology;Apr2002, Vol. 97 Issue 4, p933 

    OBJECTIVES:Celiac disease (CD) is characterized by small intestinal inflammation and mucosal atrophy. Endoscopic markers of villous atrophy are reported to be present in 88–100% of untreated celiac patients. In patients being evaluated for iron deficiency anemia (IDA), we examined whether...

  • Re: M Saginur, FAM AlRefaee, DW Spady, et al. Antitissue transglutaminase antibody determination versus upper endoscopic biopsy diagnosis of paediatric celiac disease. Paediatr Child Health 2013;18(5):246-250. Jong, Geert't // Paediatrics & Child Health (1205-7088);Aug/Sep2013, Vol. 18 Issue 7, p384 

    A letter to the editor is presented in response to the article "Antitissue transglutaminase antibody determination versus upper endoscopic biopsy diagnosis of paediatric celiac disease" in the previous issue.

  • Capsule Endoscopy Changes Patient Management in Routine Clinical Practice. David Sanders; Kapil Kapur; David Hurlstone; Mark McAlindon // Digestive Diseases & Sciences;May2007, Vol. 52 Issue 5, p1382 

    Abstract  Our objective was to evaluate the diagnostic yield and effect of capsule endoscopy on patient management in routine clinical practice. Three hundred examinations were performed (176 females; mean age, 51 years), with a median follow-up of 17 months. Indications included overt...

  • Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology. Ludvigsson, Jonas F.; Bai, Julio C.; Biagi, Federico; Card, Timothy R.; Ciacci, Carolina; Ciclitira, Paul J.; Green, Peter H. R.; Hadjivassiliou, Marios; Holdoway, Anne; van Heel, David A.; Kaukinen, Katri; Leffler, Daniel A.; Leonard, Jonathan N.; Lundin, Knut E. A.; McGough, Norma; Davidson, Mike; Murray, Joseph A.; Swift, Gillian L.; Walker, Marjorie M.; Zingone, Fabiana // Gut;Aug2014, Vol. 63 Issue 8, p1210 

    A multidisciplinary panel of 18 physicians and 3 nonphysicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British...

  • Obscure gastrointestinal bleeding persisting for a decade: a rare manifestation of a common disease. Rana, Surinder S.; Sharma, Vishal; Rao, Chalapathi; Singh, Kartar; Bhasin, Deepak K. // Annals of Gastroenterology;Jul-Sep2012, Vol. 25 Issue 3, p271 

    Celiac disease commonly presents with diarrhea but variable presentation with anemia, osteoporosis, incidental recognition, and liver function abnormalities is also known. Overt blood loss is uncommon in celiac disease. We present the case of a 60-year-old female who presented with obscure...

  • Is there a role for chromoendoscopy in the diagnosis of coeliac disease? Johnston, Alexander // Journal of Gastrointestinal & Liver Diseases;Mar2014, Vol. 23 Issue 1, p103 

    A letter to the editor is presented in response to the study titled "Is There a Role for Chromoendoscopy in the Diagnosis of Coeliac Disease?."

  • Disappointing Sensitivity of Endoscopic Markers for Villous Atrophy in a High-Risk Population: Implications for Celiac Disease Diagnosis During Routine Endoscopy. Dickey, William; Hughes, Dermot // American Journal of Gastroenterology;Jul2001, Vol. 96 Issue 7, p2126 

    OBJECTIVE: Endoscopic markers of duodenal villous atrophy (VA) can facilitate diagnosis of celiac disease during routine upper GI endoscopy. We studied their sensitivity for VA in a large series of patients undergoing GI endoscopy specifically for duodenal biopsy. Poor sensitivity in this...

  • Capsule endoscopy may allow early detection of overt lymphoma.  // Hem/Onc Today;11/10/2012, Vol. 13 Issue 21, p55 

    The article reports on a study by Maximilien Barret, M.D., MSc, of Assistance Publique-Hopitauxde Paris and colleagues, concerning intestinal mucosa assessment through capsule endoscopy to accurately diagnose celiac disease and detect overt lymphoma.

  • Celiac sprue diagnosed by wireless capsule endoscopy. Gross, Seth A; Schmelkin, Ira J; Kwak, Gina S // American Journal of Gastroenterology;Sep2003 Supplement, Vol. 98, pS151 

    An abstract of the article "Celiac Sprue Diagnosed by Wireless Capsule Endoscopy," by Seth A. Gross, Ira J. Schmelkin and Gina S. Kwak is presented.


Read the Article


Sign out of this library

Other Topics