Thorburn, D.; Feagan, B.; Marotta, P.J.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA106
Academic Journal
Background: Liver transplantation is an established intervention to improve survival in CLD. A cross sectional study of patients from this centre 1 year post-LT revealed that HRQOL in LT recipients was not superior to that in patients with CLD. Published longitudinal data on the effects of LT on HRQO/in patients with CLD is limited. HCV related CLD is now the major indication for LT. Early HCV graft re-infection post-LT is almost universal and associated with a more aggressive natural history. Aim: To establish whether LT improves HRQOL in patients with CLD on prospective longitudinal study; and patients undergoing LT for HCV related CLD suffer from impaired HRQOL compared with patients undergoing LT for indications not associated with early disease recurFence. Methods: A prospective longitudinal study of HRQOL utility measures was performed in patients undergoing LT for CLD. All patients underwent the following utility measurement techniques: feeling thermometer (FT), time-trade off (TTO) and standard gamble (SG), preLT and post-LT. Mean ut ty scores, where "0" represents death and "1'" perfect health, were compared using the student t-test. Results: The Child-Pugh class (CPC) distribution pre-LT was comparable between the 2 groups. A significant improvement in all three parameters was observed in both groups post-LT compared with pre-LT measures (all p < 0.004) (see Table). Conclusions: On longitudinal study, patients with CLD undergoing LT experience a dramatic and significant improvement in HRQOL at 1 year, which is comparable in patients undergoing LT for HCV related CLD.


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