TITLE

FREQUENCY OF HEAVY DRINKING AND OF LIVER DISEASE IN RELATIVES OF HEAVY DRINKERS WITH AND WITHOUT LIVER DISEASE

AUTHOR(S)
Bhala, N.; Rahman, A.; Jones, J.; Bradley, M.P.; Peck, R.J.; Gleeson, D.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA102
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Only a minority of heavy drinkers develop alcoholic liver disease (ALD): 13.5% in one large epidemiological study. The variable predisposition is thought to have a genetic component but this has not been quantified. Aim: Comparison of family histories of heavy drinking and of liver disease between heavy drinkers with and without liver disease. Methods: Questionnaire applied to two groups of heavy drinkers (> 60 U/wk (M) or 40 U/wk (F) for > 5 years), one with decompensated ALD (patients: n = 163, 114 M, age 48±SD10 year) and one with no clinical, laboratory or ultrasound evidence of serious liver disease (controls: n = 121,92 M, age 49±9 year). We asked subjects to classify the drinking habits of their parents and siblings as abstinent, social, light, moderate or heavy; and also, whether any relatives had liver disease, available details of which were sought. ALD was defined as otherwise unexplained liver disease in a heavy drinker. Results: See Table. ALD expressed as percentage of heavy drinking relatives; all liver disease as % of all informative relatives. Conclusion: Although compatible with a genetic component to predisposition to ALD these data suggest that this component is modest.
ACCESSION #
9747982

 

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