TITLE

FATTY LIVER IN A FEMALE BANGLADESHI POPULATION: A MANIFESTATION OF INSULIN RESISTANCE?

AUTHOR(S)
Wang, S.R.; Rampton, D.S.; Ballinger, A.B.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA101
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Southeast Asians have increased insulin resistance manifest by a high prevalence of type II diabetes mellitus and premature ischoemic heart disease. Insulin resistance also plays a key role in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD); the "two hit" theory proposes that there is accumulation of excessive hepatic fat due to insulin resistance and subsequently oxidative stress owing to reactive oxygen species. Hypothesis: This background would suggest that Bangladeshi patients are at increased risk of NAFLD and possibly progressive liver disease. Methods: 23 consecutive female Bangladeshi patients referred to the gastroenterology clinic with non-specific abdominal pain were investigated with abdominal ultrasound and liver echogenicity noted. Body mass index (BMI) was calculated and risk factors for NAFLD were noted from the medical, alcohol, and drug history. Blood was taken for blood glucose, liver biochemistry, and lipids. Results: The echogenicity of the liver was increased in 11/23 (48%) patients consistent with fatty liver. The mean age of these patients was 48 (+7) years. Only two of the patients with fatty liver had recognised risk factors (1 patient type II diabetes and 1 patient hypertriglyceridaemia). Three of the patients with fatty liver had a minor increase in serum transaminases (maximum ALT 68 U/L). BMI of the patients with fatty liver was increased (30.1 + 2.3 kg/m²) compared with those without fatty liver (26.6 + 3.2 kg/m², p = 0.02). Conclusions: In this small but unselected series of patients attending a gastroenterology clinic serving a Bangladeshi community, there was a high prevalence of fatty liver on ultrasound. Population figures have estimated a prevalence of fatty liver of only 4-16% in patients without risk factors. The high prevalence of fatty liver in Bangladeshi women may be related to increased BMI but further studies are needed both to determine the natural history and...
ACCESSION #
9747976

 

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