TITLE

EFFECTS OF BACTERIAL ENTEROTOXINS ON DISTANT (NEUROGENIC) INTESTINAL FLUID AND ELECTROLYTE TRANSPORT

AUTHOR(S)
Casburn-Jones, A.C.; Banks, M.R.; Farthing, M.J.G.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA100
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We have shown previously that CT, LT, and STa have distant effects on intestinal fluid and electrolyte transport via neural mechanisms. Intestinal transection can abolish or reduce the remote effects of CT, LT, and STa supporting a rob for intrinsic neurones of the enteric nervous system. Aim: To determine the role of vagotomy in the remote actions of CT, LT, and STa; and to determine the effects of granisetron, a selective 5-HT[sub 3] receptor antagonist, and PG 97-269, a selective VIP1 antagonist in CT induced effects on distant intestinal transport. Method: A model of remote intestinal secretion was created in anaesthetised rats. CT (50 µg/ml), LT 50 µg/ml), STa (2 ug/ml), and hyperosmolar mannitol (600 mOsm/kg), a control secretagogue, and saline (control) were placed independently in a proximal jejunal loop. A distal ileal loop was perfused with [sup 14]C-PEG to measure changes in fluid and electrolyte transport. The experiment was repeated post-vagotomy. Intraperitoneal granisetron (75 µg/kg) and intravenous PG 97-269 were given independently prior to CT. Results: Vagotomy completely inhibited STa induced ileal fluid and electrolyte transport changes but had no effect on CT and LT. Gran setron and PG 97-269 completely reversed the remote effects of CT (p < 0.05). Mannitol had no effect on distant intestinal fluid and electrolyte transport. Discussion: STa is dependent on vagal activity to mediate distant intestinal fluid and electrolyte changes. CT and LT's remote effects are independent of vagal activity but dependent on intestinal integrity and hence an intact enteric nervous system. 5-HT[sub 3] and VIP receptors are involved in the neural pathway mediating the remote actions of CT. The neural mechanisms involved in distant intestinal transport are likely to have important pathophysiological implications as CT, LT, and STa can attenuate the distal intestine's capacity to absorb excess fluid.
ACCESSION #
9747965

 

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