TITLE

UPREGULATION OF DUODENAL PROTEIN EXPRESSION OF DIVALENT METAL TRANSPORTER 1 PROTEIN IN UNTREATED COELIAC DISEASE MAY BE DUE TO A SWITCH TO A MORE MATURE MUCOSAL EPITHELIAL PHENOTYPE

AUTHOR(S)
Butterworth, J.R.; Bastin, J.M.; Townsend, A.; Sharma, N.K.; Tselepis, C.; Cooper, B.T.; Iqbal, T.H.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA100
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Not all patients with untreated coeliac disease (CD) have iron deficiency anaemia. Studies show that expression of iron cognate proteins involved in iron absorption is highest in the duodenal villi with little expression in the crypts. In untreated CD patients with normal iron indices, we hypothesised that there may be a switch to a more mature phenotype among the mucosal and crypt epithelial cells resulting in up-regulation of expression of proteins involved in iron absorption. Aims: To investigate the duodenal expression of iron cognate proteins in patients with untreated and treated CD with normal body iron indices. Methods and Patients: Immunohistochemical methods were used to assess semi-quantitative protein expression of divalent metal transporter 1 (DMT1), transferrin receptor (TfR) and ferritin in distal duodenal mucosa of untreated CD (n = 5), treated CD (n = 6), and controls (n = 13). Results: in both untreated and treated CD patients, crypt membranous, cytoplasmic, and nuclear expression of DMT1 (p < 0.04 to p < 0 0001) and crypt membranous expression of TfR (p = 0.0008) was higher compared to controls, in treated CD, villous expression of DMT1 and TlR was higher compared to controls p < 0.0001). Expression of cytoplasmic and nuclear ferritin expression was lower in untreated and treated CD compared to controls (p < 0.026 to p < 0.0001). Conclusions: This preliminary study has shown differences in duodenal mucosal expression of iron cognate proteins in untreated and treated CD compared with controls, despite similar body iron indices. Increased levels of DMT1 expression in untreated CD suggests the existence of a mature mucosal epithelial phenotype protecting against iron deficiency.
ACCESSION #
9747962

 

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