Trebble, T.; May, A.; Wootton, S.A.; Erlewyn-Lajeunesse, M.D.S.; Chakraborty, A.; Mullee, M.A.; Stroud, M.A.; Beattie, R.M.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA98
Academic Journal
Malnutrition and growth retardation is associated with increased disease activity in paediatric Crohn's disease (CD). Adequate availability of essential Fatty acids (EFA) (linoleic (LA) and α linolenic acid (αLNA)) and their derivatives (arachidonic (AA) and docosahexaenoic acid) may be required for optimum childhood growth and development, and altered plasma levels may be associated with protein energy and oedematous malnutrition. In paediatric CD the relationship of plasma concentrations of EFA, and derived fatty acids, to disease activity, nutritional status and percentage total body water (%TBW) is poorly defined. Paediatric CD patients (10.3-17.0 years) were stratified by Paediatric Crohn's Disease Activity Index as active (n = 15) and inactive (n = 15) disease groups, and assessed for nutritional status (anthropometry and bioelectrical impedance) and fatty acid composition of plasma phosphatidylcholine (PC) (by gas chromatography). Lower concentrations of αLNA were noted in active CD (0.26%) vs inactive CD (0.35%) (p = 0.044). Active CD was associated with lower triceps skinfold thickness and mid-arm muscle circumference and higher %TBW compared with inactive CD. On post hoc analysis, CD patients with a BMI centile < 50 vs > 50 demonstrated lower LA (23.3% vs 25.6%; p = 0.021) and αLNA (0.25% vs 0.34%; p = 0.025), but higher AA (9.68% vs 8.39%; p: 0.017) levels in plasma PC. Similar differences were noted in patients with a %TBW > 65 % vs < 65%. There were no differences in habitual dietary fat or energy intake between CD patient groups stratified by PCDAI, BMI centile or %TBW. Disease activity and nutritional status in paediatric CD are associated with alterations in the availability of EFA and AA that cannot be simply explained by differences in habitual dietary intake but may reflect adaptive or pathological responses. Further investigation is indicated to determine the effect of dietary intervention on modulating plasma fatty...


Related Articles

  • Nutritional Status and Growth in Pediatric Crohn's Disease: A Population-Based Study. Vasseur, Francis; Gower-Rousseau, Corinne; Vernier-Massouille, Gwenola; Dupas, Jean Louis; Merle, Veronique; Merlin, Beatrice; Lerebours, Eric; Savoye, Guillaume; Salomez, Jean Louis; Cortot, Antoine; Colombel, Jean Frederic; Turck, Dominique // American Journal of Gastroenterology;Aug2010, Vol. 105 Issue 8, p1893 

    OBJECTIVES:Growth retardation and malnutrition are major features of pediatric Crohn's disease (CD). We examined nutritional and growth parameters from diagnosis to maximal follow-up in a population-based pediatric cohort, and we determined predictive factors.METHODS:A total of 261 patients (156...

  • Crohn's disease--40 years on.  // British Medical Journal;10/21/1978, Vol. 2 Issue 6145, p1106 

    Focuses on the management and treatment of Crohn's disease. Symptoms of the disease; Emphasis on malnutrition as a cause of the disease; Complications associated with the disease.

  • Normal energy intake in undernourished patients with Crohn's disease. Jones, L.A.; Harries, A.D.; Rhodes, J.; Heatley, R.V. // British Medical Journal (Clinical Research Edition);1/21/1984, Vol. 288 Issue 6412, p193 

    Investigates the energy intake in undernourished patients with Crohn's disease. Factors contributing to the undernutrition in patients with Crohn's disease; Usefulness of enteral supplementation in increasing weight of patient's with Crohn's disease; Comparison of energy intakes between...

  • Mid-arm circumference as simple means of identifying malnutrition in Crohn's disease. Harries, A.D.; Jones, L.; Heatley, R.V.; Rhodes, J.; Fitzsimons, E. // British Medical Journal (Clinical Research Edition);11/6/1982, Vol. 285 Issue 6351, p1317 

    Investigates the identifying malnutrition in Crohn's disease using mid-arm circumference. Emphasis on malnutrition in patients; Manifestation of weight loss; Study of 106 outpatients with Crohn's disease.

  • Nutritional Status and Growth in Korean Children with Crohn's Disease: A Single-Center Study. Seung Min Song; Young Kim; Seak Hee Oh; Kyung Mo Kim // Gut & Liver;Sep2014, Vol. 8 Issue 5, p500 

    Background/Aims: Malnutrition and growth retardation are important issues in treating pediatric Crohn's disease (CD). Thus, we aimed to investigate the prevalence of various nutritional and growth parameters at the time of diagnosis in Korean children with CD. Methods: Seventy-one children (<18...

  • Alimentaci�n y enfermedad inflamatoria intestinal. Tratamiento y control nutricional de la EII en pediatr�a. Parte 1. Solar Boga, A.; Bautista Casasnovas, A.; Bouso�o Garc�a, C. // Acta Pedi�trica Espa�ola;sep2012, Vol. 70 Issue 8, p299 

    The link which exists between inflammatory bowel disease (IBD) and diet is a complex one. Publications on this issue are scarce and contradictory, even more so in the paediatric field. This paper first provides a review of the existing scientific evidence concerning the debatable role of diet as...

  • Nutritional Aspects in Inflammatory Bowel Disease. Hojsak, Iva; Shamir, Raanan // European Paediatrics;2010, Vol. 4, p45 

    Inflammatory bowel disease (IBD) in children has different manifestations from in adults. This is mainly due to the impact of malnutrition on growth retardation and pubertal delay, which can usually be treated with adequate enteral nutrition (EN). EN has a proven role in the treatment of Crohn's...

  • Rapid Recovery of a Rectovaginal Fistula with Infliximab in a Patient with Crohn's Disease. Hagiu, Claudia; Badea, Radu; Serban, Alexandru; Petrar, Sabina; Andreica, Vasile // Journal of Gastrointestinal & Liver Diseases;Sep2010, Vol. 19 Issue 3, p329 

    We present the case of a female patient diagnosed with colonic Crohn's disease, having a clinical evolution with many recurrences and in whom conventional therapy had failed. The patient was admitted in our department 4 years after the onset of the disease, with an altered general state,...

  • Gastric Emptying in Childhood Inflammatory Bowel Disease: Nutritional and Pathologic Correlates. Gryboski, Joyce D.; Burger, JoAnne; MeCallum, Richard; Lange, Robert // American Journal of Gastroenterology;Sep1992, Vol. 87 Issue 9, p1148 

    To determine the incidence of gastric emptying abnormalities in children with inflammatory bowel disease, we performed dual liquid/solid-emptying studies on 25 children with ulcerative colitis (UC) and on 45 with Crohn's disease (CD) over a 6-yr period. Nutritional parameters were evaluated...


Read the Article


Sign out of this library

Other Topics