Carroll, D.; Spicer, R.D.; Cairns, P.; Corfield, A.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA93
Academic Journal
Introduction: Faecal calprotectin levels are known to be markedly elevated in children and adults with inflammatory bowel disease. Faecal calprotectin levels are an indirect marker of gastrointestinal inFlammation. Necrotising entercolitis (NEC) is a severe condition of neonatal like characterised by gastrointestinal inflammation and ischaemia. Optimal management for this condition relies upon prompt recognition and early institution of conservative treatment. This study aims to evaluate the potential usefulness of faecal calprotectin levels to diagnose NEC. Methods: Stool samples were collected from neonates with written parental consent on D1, D7 and D14 of life. Any children with suspected NEC had additional stool samples collected. Feed type, gestational age, and postnatal age were recorded. Stool samples were stored frozen at -20°C and analysed using the PhiCal ELISA based kit. Faecal calprotectin levels for each patient were calculated against a standard curve run with each assay. Statistical analysis of data was performed using SPSS for Windows version 10. Results: The presence of NEC is associated with a statistically significant increase in faecal calprotecitn levels compared to matched controls (p < 0.001). Faecal calprotectin levels in infants are considerably higher than the reported adult reference range. This is most marked in stool samples collected on the first day of life. Faecal calprotectin levels fall as postnatal age increases. Conclusions: Faecal calprotectin levels are a useful tool for diagnosing NEC in infants. Faecal calprotectin levels are significantly higher in neonatal life than in healthy adult controls.


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