O'Brien, A.J.; Lamb, E.J.; Muller, A.F.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA92
Academic Journal
Introduction: The irritable bowel syndrome (lBS) is a heterogeneous disorder involving genetics, infection, mucosal inflammation, and visceral hypersensitivity. We havepreviously demonstrated tubular proteinuria in patients with inflammatory bowel disease (IBD). This study examined whether tubular proteinuria may be a feature of lBS. Methods: 53 control subjects (age range 20-65 years) and 21 patients with lBS (M:F 9:12 age range 16-64 years (NS)) were recruited. Subjects with known renal disease, hypertension, diabetes, or microbiological evidence of urinary infection were excluded. The lBS group patients all fulfilled the Rome II criteria for diagnosis. None gave a history of preceding gastroenteritis. Many patients underwent radiological or endoscopic evaluation. All subjects provided the second voided urine of the morning. Urinary concentrations of the protein α1-microglobulin (cd-M) were measured using rate nephelometric immunoassay and corrected for urinary concentration by measurement of creatinine (upper reference limit 1.5 mg/mmol). Blood samples were analysed for biochemical and haematological indices including C-reactive protein. Statistical analysis was by unpaired T-test. Results: None of the lBS patients over a 3 year follow up period were reclassified with IBD. All had normal haematochemical parameters. Mean (+/- SD) urinary α1-M concentrations were significantly higher in lBS than controls (lBS (1.17 +/- 0.65 mg/mmol; controls 0.75 +/- 0.36 mg/mmol, p <0.01) and exceeded 1.5 mg/mmol in 7 patients. Conclusions: Urinary α1-M concentration is elevated in lBS, suggesting the presence of renal tubular injury.


Related Articles

  • Inflammation and the Neuroimmune Systems. Weiss, Decker // Townsend Letter;Jun2014, Issue 371, p61 

    The article looks at the correlation of chronic infections and inflammation with vascular disease. Topics covered include several diseases associated with inflammation, details of a case study involving an athletic 62-year-old woman with history of irritable bowel, sports injuries and bleeding...

  • Newsflash.  // Good Health (Australia Edition);Dec2010, p16 

    The article reports that according to a research, tiny inflammations in the inner lining of gut could be one of the causes of irritable bowel syndrome.

  • Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFÉ‘. Swan, Caroline; Duroudier, Nathalie P.; Campbell, Eugene; Zaitoun, Abed; Hastings, Margaret; Dukes, George E.; Cox, Joanne; Kelly, Fiona M.; Wilde, Jonathan; Lennon, Mark G.; Neal, Keith R.; Whorwell, Peter J.; Hall, Ian P.; Spiller, Robin C. // Gut;Jul2013, Vol. 62 Issue 7, p985 

    Objectives The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which...

  • Probiotics in the Management of Irritable Bowel Syndrome: A Review of Clinical Trials. Hamilton-Miller, J. M. T. // Microbial Ecology in Health & Disease;Dec2001, Vol. 13 Issue 4, p212 

    Irritable bowel syndrome is a common condition of unknown aetiology, the medical management of which is unsatisfactory. Despite evidence that a disturbance of intestinal flora may be responsible for the initiation and or chronicity of the distressing symptoms, little attention has been paid to...

  • The effect of PDIA3 gene knockout on the mucosal immune function in IBS rats. Zhao-Meng Zhuang; Xiao-Teng Wang; Lu Zhang; Li-Yuan Tao; Bin Lv // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 5, p6866 

    Objective: To observe the changes of intestinal inflammation on PDIA3 gene knockout IBS rats and its effect on immune function. Methods: 36 SD rats were randomly divided into four groups: the control group (n = 8); IBS- empty virus group (IBS-GFP, which); IBS-PDIA3 knockout group (n = 12); IBS-...

  • Serotonin transporter gene polymorphism in irritable bowel syndrome. Pata, Cengiz; Erdal, M. Emin; Derici, Ebru; Yazar, Aziz; Kanık, Arzu; Ulu, Oğuz // American Journal of Gastroenterology;Jul2002, Vol. 97 Issue 7, p1780 

    OBJECTIVES:Serotonin is a key mediator of intestinal peristalsis, and after it is secreted, it is effectively cleansed from the neuronal gap by means of a high affinity substance called serotonin transporter (SERT), which depends on the Na+ and Cl− ions localized in the presynaptic...

  • Inflammatory Bowel Disease. Sachar, David B.; Jewell, Derek; Gasche, Christoph; Braun, Jonathan // International Journal of Inflammation;2012, p1 

    An introduction is presented in which the editors discuss various papers within the issue on topics including pharmacological therapy for inflammatory bowel disease (IBD), prevalence of ulcerative colitis (UC), and Crohn's disease (CD) among Hispanics and intestinal dysbiosis.

  • Post-infectious irritable bowel syndrome. Thabane, Marroon; Marshall, John K. // World Journal of Gastroenterology;8/7/2009, Vol. 15 Issue 29, p3591 

    Post-infectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS to range between 5% and 32%. The mechanisms underlying the development of PI-IBS are not fully...

  • Lack of Association between Interleukin 12 C(-1188)A Polymorphism and Irritable Bowel Syndrome. Barkhordari, Elham; Amirzargar, Ali Akbar; Ebrahimi-Daryani, Naser; Mahmoudi, Mahdi; Ansaripour, Bita; Alighardashi, Maryam; Ahmadi-Ashtiani, Hamid Reza; Bashashati, Mohammad; Rezaei, Nima // Avicenna Journal of Medical Biotechnology;Jan-Mar2011, Vol. 3 Issue 1, p45 

    Irritable Bowel Syndrome (IBS) is a functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. This study was performed to investigate the important role of interleubin-12 (IL-12) in intestinal inflammation. For this study seventy one patients with...


Read the Article


Sign out of this library

Other Topics