TITLE

RENAL TUBULAR PROTEINURIA IN PATIENTS WITH IRRITABLE BOWEL SYNDROME

AUTHOR(S)
O'Brien, A.J.; Lamb, E.J.; Muller, A.F.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA92
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: The irritable bowel syndrome (lBS) is a heterogeneous disorder involving genetics, infection, mucosal inflammation, and visceral hypersensitivity. We havepreviously demonstrated tubular proteinuria in patients with inflammatory bowel disease (IBD). This study examined whether tubular proteinuria may be a feature of lBS. Methods: 53 control subjects (age range 20-65 years) and 21 patients with lBS (M:F 9:12 age range 16-64 years (NS)) were recruited. Subjects with known renal disease, hypertension, diabetes, or microbiological evidence of urinary infection were excluded. The lBS group patients all fulfilled the Rome II criteria for diagnosis. None gave a history of preceding gastroenteritis. Many patients underwent radiological or endoscopic evaluation. All subjects provided the second voided urine of the morning. Urinary concentrations of the protein α1-microglobulin (cd-M) were measured using rate nephelometric immunoassay and corrected for urinary concentration by measurement of creatinine (upper reference limit 1.5 mg/mmol). Blood samples were analysed for biochemical and haematological indices including C-reactive protein. Statistical analysis was by unpaired T-test. Results: None of the lBS patients over a 3 year follow up period were reclassified with IBD. All had normal haematochemical parameters. Mean (+/- SD) urinary α1-M concentrations were significantly higher in lBS than controls (lBS (1.17 +/- 0.65 mg/mmol; controls 0.75 +/- 0.36 mg/mmol, p <0.01) and exceeded 1.5 mg/mmol in 7 patients. Conclusions: Urinary α1-M concentration is elevated in lBS, suggesting the presence of renal tubular injury.
ACCESSION #
9747906

 

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