TITLE

EFFECT OF FIBRE DIET ON NEOPLASIA: CELL PROLIFERATION AND CRYPT FISSION IN MIN MICE

AUTHOR(S)
Bashir, O.; FitzGerald, A.J.; Goodlad, R.A.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA92
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The precise nature and magnitude of the relationship between specific fibre intake and risk of colorectal cancer have not been clearly established. Some studies have shown increased risk rather than protection in man and in animals. One possible explanation is that dietary fibre can modify the process of crypt fission, by which crypts can duplicate themselves, and increase cell proliferation which, can be a promoter of carcinogenesis. Methods: We have used the Min mouse (C57BK/6J-ApcMin) to investigate the actions of a chow diet, a fibre-free semisythetic diet and semi-synthetic diets supplemented with apple fibre or wheat bran fibre on polyp progression, cell proliferation and crypt fission. Forty Min mice, 4 weeks old, were divided into 4 groups and Fed the four diets for 8 weeks. The number and size of polyps in the small and large intestines were scored as were the number of native mitoses and the percentage of branching crypts. Results: The guts of Min mice fed the fibre-free semi-synthetic (SS) diets were lighter than those of the chow fed. There were fewer polyps in the semisythetic diet compared to the chow fed (p < 0.050). There were more polyps in small intestine of the Min mice fed apple fibre (p = 0.07) and bran (p = 0.014). In the colon there were 50% more polyps in the apple fibre group (NS) and 188% more in the bran fed. There was a significant increase in cell proliferation in the colon of the apple fed group with little change in colonic crypt fission. Crypt fission in the small intestine was significantly decreased by the apple and bran fibres (p < 0.05). Conclusion: Both apple fibre and bran were associated with increased polyp number in the small intestine and colon but the actions of altered crypt fission are still not clear.
ACCESSION #
9747902

 

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