TITLE

VEGF-C EXPRESSION AND TUMOUR SPROUTING ARE USEFUL INDICATORS FOR NODAL INVOLVEMENT IN SUBMUCOSAL INVASIVE COLORECTAL CARCINOMAS

AUTHOR(S)
Ishikawa, H.; Fujii, H.; Koyama, F.; Mukougawa, T.; Matsumoto, H.; Kobayashi, T.; Kuniyasu, H.; Nakajima, Y.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA91
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: It is difficult to estimate the adequacy of endoscopic resection for submucosal invasive colorectal carcinoma (SICC) because about 10% of patients with SICCs have nodal involvement. VEGF-C is suggested to nave an important role For tumour lymphangiogenesis and tumour sprouting has regained attention as an indicator of lymphatic invasion (LI). To investigate risk factors of nodal involvement in SICC, we have examined the relationship between nodal involvement and tumour status of VEGF expression and tumour sprouting along with clinicopathological factors. Methods: Sixty-eight consecutive patients with SICCs underwent either surgical or endoscopic resection between 1990 and 2001. Patients were aged between 38 and 80 years (median 65), 44 were male. 36 tumours were polypoid. Tumours were classified by the absolute amount of submucosal invasion both in their depth and width (depth; sm1 ≤ 0.5 mm, 0.5 < sm2 < 1.0 mm, 1.0 mm ≤ sm3, width; sma ≤ 1.0 mm, 1.0 < smb < 3.0 mm, 3.0 mm ≤ smc) and were immunohistochemically stained for VEGF-C and Cytokeratin 8/18. Results: Of 68 tumours 7 had nodal involvement. Among clinocopathologocal factors, the ratio of nodal involvement of polypoid tumours (1/35) was lower than that of non-polypoid (6/35; p = 0.044). Tumours were divided into sm1(14), sm2(29), sm3(25) in the depth, sma(18), smb(27), smc(23) in the width. There was no nodal involvement in sm1 and sm2a(6). As tumour invasion increased in depth and width, positive cases of LI, venous invasion (VI) and nodal involvement increased. VEGF-C expression showed positive correlation with LI, VI and nodal involvement and tumour sprouting showed positive correlation with LI and nodal involvement. Both VEGF-C expression (6/7, 85.7%) and tumour sprouting (5/7, 71.4%) showed high specificity for nodal involvement. Conclusion: VEGF-C expression and tumour sprouting are useful in predicting nodal involvement in SICC.
ACCESSION #
9747895

 

Related Articles

  • Diagnostic significance of gently sloping depression and irregular margin in superficial elevated colorectal tumors. Nakahara, Takako; Aoyama, Nobuo; Maekawa, Shuji; Tamura, Takao; Shirasaka, Daisuke; Kuroda, Kohei; Nishioka, Chiharu; Morita, Yoshinori; Kasuga, Masato // International Journal of Colorectal Disease;Jan2007, Vol. 22 Issue 1, p25 

    Recently, superficial elevated colorectal tumors have been increasingly diagnosed after improvements in endoscopic instruments and techniques. However, their biological characteristics remain obscure and it is difficult to predict malignant potential. The aim of this study is to clarify the...

  • Incomplete Colonoscopy in Patients with Occlusive Colorectal Cancer: Usefulness of CT Colonography According to Tumor Location. Joo Hee Kim; Won Ho Kim; Tae Il Kim; Nam Kyu Kim; Kang Young Lee; Myeong-Jin Kim; Ki Whang Kim // Yonsei Medical Journal;12/31/2008, Vol. 48 Issue 6, p934 

    Purpose: We sought to evaluate the clinical usefulness of CT colonography (CTC) after incomplete conventional colonoscopy (CC) for occlusive colorectal cancer (CRC) according to the tumor location. Materials And Methods: Seventy-five patients with occlusive CRC underwent subsequent CTC...

  • Anatomical distribution of colorectal cancer over a 10 year period in a district general hospital: is there a true "rightward shift"? Gomez, D.; Dalal, Z.; Raw, E.; Roberts, C.; Lyndon, P. J. // Postgraduate Medical Journal;Nov2004, Vol. 80 Issue 949, p667 

    Introduction: Recent studies of patients with colorectal cancer have suggested a shift towards the proximal colon and an increase in the incidence of right sided colon cancer. This study aimed to determine the anatomical distribution of colorectal cancer over a 10 year period in a district...

  • Screening for colorectal cancer. Saliangas, K. // Techniques in Coloproctology;Nov2004 Supplement 1, Vol. 8, ps10 

    A review of the literature regarding the screening strategies for colorectal cancer (CRC), particularly for average risk individuals, is analysed. The advantages and disadvantages or limitations of screening modalities for CRC, such as faecal occult blood testing (FOBT) with guaiac-based tests...

  • Laparoscopic left lateral hepatic lobectomy for metastatic colorectal tumor. Cadière, G.B.; Torres, R.; Dapri, G.; Capelluto, E.; Himpens, J. // Surgical Endoscopy;Jan2005, Vol. 19 Issue 1, p152 

    Background: The growth of experience in laparoscopic surgery, technological improvements in Iaparoscopic instruments, and the application of laparoscopy to oncology surgery arc responsible for the new challenge of laparoscopic liver surgery. Several series of laparoscopic liver resections have...

  • Value of a Routine Follow-up Endoscopy Program for the Detection of Recurrent Colorectal Carcinoma. Barkin, Jamie S.; Cohen, Michael E.; Flaxman, Mitchell; Lindblad, Anne S.; Mayer, Robert J.; Kalser, Martin H.; Steinberg, Seth M. // American Journal of Gastroenterology;Dec1988, Vol. 83 Issue 12, p1355 

    Four hundred fifty-two patients with surgically resected colon or rectal cancer were evaluated to determine the incidence of intraluminal recurrences and the utility of a routine endoscopy screening program for detecting such recurrences. At the time of analysis, recurrent disease was found in...

  • Magnifying Chromoendoscopic Findings of Early Gastric Cancer and Gastric Adenoma. Ohnita, Ken; Isomoto, Hajime; Shikuwa, Saburo; Yamaguchi, Naoyuki; Nakayama, Toshiyuki; Nishiyama, Hitoshi; Okamoto, Kenta; Fukuda, Eiichiro; Takeshima, Fuminao; Hayashi, Tomayoshi; Kohno, Shigeru; Nakao, Kazuhiko // Digestive Diseases & Sciences;Sep2011, Vol. 56 Issue 9, p2715 

    Purpose: In the field of colorectal cancer and adenoma, Kudo's classification of pit pattern with magnifying chromocolonoscopy using crystal violet (CV) staining is now accepted. Magnifying endoscopy using narrow band imaging has been used for the diagnosis of gastric carcinoma; the...

  • Hyperplastic Polyps, Serrated Adenomas, and the Serrated Polyp Neoplasia Pathway. Huang, Christopher S.; O'Brien, Michael J.; Shi Yang; Farraye, Francis A. // American Journal of Gastroenterology;Nov2004, Vol. 99 Issue 11, p2242 

    (Am J Gastroenterol 2004;99:2242-2255)

  • Do distal adenomas mandate total colonoscopy? Khan, A.; Shrier, I.; Gordon, P.H. // Surgical Endoscopy;Jun2003, Vol. 17 Issue 6, p886 

    Background: Distal adenomas have been considered markers of proximal neoplasms. It also has been suggested that patients with small, distal adenomas do not require proximal examination of the colon. This study was conducted to determine the validity of the latter recommendation. Methods: From a...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics