TITLE

EVIDENCE OF OESOPHAGEAL STIMULUS INTENSITY DEPENDANT RESPONSE IN THE HUMAN ANTERIOR CINGULATE AND PRIMARY SOMATOSENSORY CORTEX

AUTHOR(S)
Coen, S.J.; Gregory, L.J.; Hall, D.; Yaguez, L.; Amaro, E.; Smale, S.; Williams, S.C.R.; Thompson, D.G.; Aziz, Q.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA86
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Functional Magnetic Resonance Imaging (fMRI) can be used to objectively quantify perception of visceral sensation. However, the neural correlates of varying, quantifiable, intensities of visceral stimulation have remain unclear and the regions involved in encoding of stimulation intensity are not fully understood. Aims: To determine the neural correlates of varying intensities of oesophageal stimulation using fMRI. Methods: 7 healthy volunteers participated in the study. The protocol consisted of four conditions. During each condition one of four balloon distension intensities, obtained by dividing the difference between sensory (0%) and pain thresholds (100%) into 4 levels at 25% increments ie 25%, 50%, 75%, and 100% were used to stimulate the distal oesophagus. A modified bock design was employed where each "active" and "rest" phase was repeated five times. This design was employed four times, once for each intensity. Behavioural data measuring the subjective perception of the stimulus was acquired using visual analogue scales (VAS). Results: VAS scores increased progressively with increasing stimulation intensities (p < 0.001). In response to 100% and 75% stimulation intensity, activation was seen in the anterior cingulate gyrus (ACG) (BA 24 32) bilatera insula suppementary motor cortex (SMA), thalamus primary and secondary sensorory cortices (SI and SII) and dorsolateral' prefrontal cortex (DLPFC). 50% and 25% intensity (non-painful) stimuli activated the same regions to a lesser extent with the exception of the thalamus, and SII, and additional activation in the inferior frontal gyrus. Further analysis revealed that there was a significant trend (p < 0.05) of an increase in cerebral activity with an increase in stimulation intensity, in the ACG (BA24], and SI (bilateral). Conclusions: Visceral stimulation results in a complex pattern of cerebral activation that is similar across varying levels of stimulation intensity. The ACG and SI, both...
ACCESSION #
9747862

 

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