Coen, S.J.; Gregory, L.J.; Hall, D.; Yaguez, L.; Amaro, E.; Smale, S.; Williams, S.C.R.; Thompson, D.G.; Aziz, Q.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA86
Academic Journal
Introduction: Functional Magnetic Resonance Imaging (fMRI) can be used to objectively quantify perception of visceral sensation. However, the neural correlates of varying, quantifiable, intensities of visceral stimulation have remain unclear and the regions involved in encoding of stimulation intensity are not fully understood. Aims: To determine the neural correlates of varying intensities of oesophageal stimulation using fMRI. Methods: 7 healthy volunteers participated in the study. The protocol consisted of four conditions. During each condition one of four balloon distension intensities, obtained by dividing the difference between sensory (0%) and pain thresholds (100%) into 4 levels at 25% increments ie 25%, 50%, 75%, and 100% were used to stimulate the distal oesophagus. A modified bock design was employed where each "active" and "rest" phase was repeated five times. This design was employed four times, once for each intensity. Behavioural data measuring the subjective perception of the stimulus was acquired using visual analogue scales (VAS). Results: VAS scores increased progressively with increasing stimulation intensities (p < 0.001). In response to 100% and 75% stimulation intensity, activation was seen in the anterior cingulate gyrus (ACG) (BA 24 32) bilatera insula suppementary motor cortex (SMA), thalamus primary and secondary sensorory cortices (SI and SII) and dorsolateral' prefrontal cortex (DLPFC). 50% and 25% intensity (non-painful) stimuli activated the same regions to a lesser extent with the exception of the thalamus, and SII, and additional activation in the inferior frontal gyrus. Further analysis revealed that there was a significant trend (p < 0.05) of an increase in cerebral activity with an increase in stimulation intensity, in the ACG (BA24], and SI (bilateral). Conclusions: Visceral stimulation results in a complex pattern of cerebral activation that is similar across varying levels of stimulation intensity. The ACG and SI, both...


Related Articles

  • HIGH-RESOLUTION MR IMAGING OF ARTERY WALL LESIONS WITH INTRAVASCULAR ANTENNAS. Chaabane, L.; Serfaty, J.M.; Marguet, C.; Douek, P.; Briguet, A. // Acta Radiologica;Apr2000 Supplement 422, Vol. 41, p69 

    Describes an approach for high-resolution magnetic resonance imaging of artery wall lesions using an endovascular probe placed into the arterial lumen. Probe design; Image acquisition; Quality of images obtained.

  • Bold insights. Raichle, Marcus E. // Nature;7/12/2001, Vol. 412 Issue 6843, p128 

    Provides information on functional magnetic resonance imaging (fMRI), which is a tool for imaging brain activity and measures the oxygen in the blood in the brain. Analysis of several aspects of neuronal activity; Major determinants of the fMRI signal; Causes of the increase of blood oxygen...

  • Editorial. Sarkar, Deepayan // R Journal;Dec2014, Vol. 6 Issue 2, p3 

    An introduction to the journal is presented in which the guest editor discusses the different uses of functional magnetic resonance imaging (fMRI).

  • Clinical Value of Routine Preoperative Magnetic Resonance Imaging in Adolescent Idiopathic Scoliosis. Do, Twee; Fras, Christian; Burke, Stephen; Widmann, Roger F.; Rawlins, Bernard; Boachie-Adjei, Oheneba // Journal of Bone & Joint Surgery, American Volume;Apr2001, Vol. 83-A Issue 4, p577 

    Background: The prevalence of intraspinal pathology associated with scoliosis has been reported to be as high as 26% in some series, and, on the basis of this finding, preoperative magnetic resonance imaging is used in the screening of patients with adolescent idiopathic scoliosis. However, this...

  • Magnetic resonance direct thrombus imaging was accurate in suspected deep venous thrombosis. Kearon, Clive // ACP Journal Club;Jul/Aug2002, Vol. 137 Issue 1, p33 

    Provides information on a study that investigated whether magnetic resonance direct thrombus imaging is an accurate diagnostic test in patients with suspected deep venous thrombosis. Study design and setting; Description of test and diagnostic standard; Main outcome measures; Main results;...

  • The analysis of functional magnetic resonance images. Rabe-Hesketh, S.; Bullmore, E.; Brammer, M.; Bullmore, E T; Brammer, M J // Statistical Methods in Medical Research;1997, Vol. 6 Issue 3, p215 

    Functional magnetic resonance imaging (fMRI) is a powerful technique for measuring brain activity associated with the performance of different mental tasks. We briefly describe this technique and the images it produces and review methods of analysis that have been applied to fMRI data....

  • Detecting activation in fMRI data. Worsley, K.J. // Statistical Methods in Medical Research;Oct2003, Vol. 12 Issue 5, p401 

    We present a simple approach to the analysis of fMRI data collected from several runs, sessions and subjects. We take advantage of the spatial nature of the data to reduce the noise in certain key parameters, achieving an increase in degrees of freedom for a mixed effects analysis. Our main...

  • The Value of MRI in diagnosing vascular abnormalities causing Stridor. Dembinski, J.; Kroll, M.; Hieronimi, G. // European Journal of Pediatrics;1998, Vol. 157 Issue 6, pA519 

    Comments on an article by R. P. Beekman et al. that compared magnetic resonance imaging (MRI) to other techniques such as barium oesophagogram and bronchoscopy. Causes of stridor in infancy and childhood; How changes of the tracheal and bronchial lumina can be verified; Diagnostic value of the...

  • The Technological Edge.  // Medical Device Technology;Sep2001, Vol. 12 Issue 7, p20 

    Focuses on the development of magnetic resonance imaging (MRI), the versatile diagnostic system for obtaining tissue images in London, England. Compatibility of the method with endoscopes; Clinical trials of the prototype MRI-compatible endoscope; Advantage of the method on medical procedures.


Read the Article


Sign out of this library

Other Topics