Bassi, A.; Kamarawa, H.; Pazmany, L.; Bodger, K.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA83
Academic Journal
Background: Ghrelin, a hormone secreted mainly from the gastric fundus, is an inducer of growth hormone release and acts as an orexigenic gut-brain signal to stimulate appetite. We speculate that H pylori infection may downregulate gastric ghrelin expression, thereby providing a potential mechanism for extraintestinal effects of the infection (eg growth delay in childhood). Methods: Subjects attending for gastroscopy were recruited. Two fundic biopsies were taken for RNA extraction and two antral biopsies for H pylori status. RNA was reverse transcribed and cDNA subject to quantitative real-time PCR with results normalised for the housekeeping gene hHPRT. Ghrelin primers were: Fwd: 5'-ACAACTCCT TGCAGCTCC-3'; Rev:5'-ATCTTCATGAAGGTAGRCAGTC-3'. Results: Nine subjects (4 HpPos) have been studied so far (Age: 32-73 years; BMI 23-32 kg/m2). A trend towards lower median expression (ghrelin/HPRT ratio) in H pylori positive versus negative subjects is apparent (p = NS). Conclusions: Based on these preliminary findings, H pylori infection may be associated with downregulation of gastric fundic ghrelin expression. If this observation is confirmed (and is associated with reduced gastric ghrelin secretion) this phenomenon may contribute to extraintestinal manifestations of the infection via reduced GH release and/or via disturbances in the regulation of appetite and energy homeostasis.


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