Ong, J.P.L.; Ahmed, W.; Walker, M.; Owens, D.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA82
Academic Journal
Background: Resistance to antibiotics can be a major problem in the treatment of bacteria infections. As the use of antibiotics increases, bacterial resistance to these agents is rising and in many cases is responsible for the failure of treatment regimes. Although the treatment of H Pylori infection requires the use of more than one antibiotic to obtain adequate eradication rates, the efficacy of currently used antibiotics combination has been shown to be reduced by resistance to one of the antibiotics used. Aim: To evaluate the antibiotic resistance to H Pylori in the past 4 years in North Wales. Method: Central database of all patients who are H Pylori positive over the past 4 years in two district general hospitals in North Wales. Minimum inhibitory concentration (MIC) of amoxycillin, metronidazole, tetracycline, and erytromycin were determined by agar dilution method. Results: A total of 888 H Pylori organism isolated. Of those, 147 had no sensitivities due to failure of the organism to grow on subculture. Primary resistance rates were: metronidazole 12.6%, erythromycin 6.7%, amoxycillin 0.6%, and tetracycline 0.7%. There was an overlap with organisms resistant to both metonidazole+erythromycin (6.8% of total of these groups); metronidazole+tetracycline (2.3% of total of these groups) and erythromycin+amoxicillin (1.9% of total of these groups). Conclusion: A proportion of patients from North Wales were infected with resistant strain of H Pylori. The higher resistance rate to metronidazole and this used in combination with erythromycin have both proved not to be effective for eradication therapy of H Pylori. Amoxicillin and tetracycline are useful component of treatment regimens in this area. No significant change in resistance rates during the period of investigation were observed. Antibiotic resistance monitoring is very important to ensure effective eradication of H Pylori infection.


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