Marakis, G.; Walker, A.; Booth, J.C.L.; Wright, J.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA81
Academic Journal
Background: Dyspepsia is a common condition but can be a difficult symptom to treat although antacids or pro-kinetics are often used. Recent data from Germany suggest that high doses of artichoke leaf extract (ALE) can reduce symptoms of dyspepsia. Aim: To investigate the efficacy of Iow dose intervent on with ALE on amelioration of dyspeptic symptoms and improvement of quality of life. Design of Study: Open, dose ranging postal study in patients with self-reported dyspepsia recruited through the media (articles in local and national newspapers). Methods: The Nepean Dyspepsia Index and the State-Trait Anxiety were assessed at baseline and alter 2 months of treatment with ALE to assess the efficacy of the intervention. Volunteers were randomly allocated to receive either 320 or 640 mg of the extract daily. Results: Of the 516 participants, 454 completed the study. In both dosage groups, there was a significant reduction of all dyspeptic symptoms, with an average reduction of 40% in global dyspepsia score. There were no differences in the outcome measures between the two groups. Health related quality of life was significantly improved in both groups. Conclusion: This open study demonstrated that ALE may ameliorate upper gastrointestinal symptoms and improve quality of life in healthy subjects suffering from dyspepsia. Further double blind, placebo controlled studies are needed to confirm these results. Nevertheless, these results hold promise of a safe new approach to dyspepsia in primary health care.


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