Dor, R.; Blanshard, C.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA79
Academic Journal
Background: Our current guidelines advocate a "test and treat" in young patients with dyspepsia without alarm symptoms. Most GPs use H pylori serology as the test of choice, which has not been validated for our population. Aims: To determine the sensitivity and specificity of the serological assay in a multiethnic population. Patient and Methods: 240 patients (97 native Caucasians and 143 non-Caucasians), with dyspepsia and no previous history of H pylori treatment referred to the hospital for an upper gastrointestinal endoscopy had blood sent for H pylori serology. At endoscopy biopsies were taken for rapid urease testing (CLO®) along with histology. Patients' ethnic group was also established by a short questionnaire. Results: 145 patients were found to be positive for H pylori on the basis of serology, however, only 128 proved positive histologically or by urease testing. Conclusions: H pylori serology is an unreliable test for predicting H pylori infection. This is particularly so in a multiethnic population where the specificity is much lower. Therefore, other non-invasive, more reliable ways of diagnosing H pylori infection should be used preferentially.


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