Sutherland-Craggs, A.; Mansfield, J.C.; Donaldson, P.T.; Daly, A.; Francis R, R.; Thompson, N.P.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA70
Academic Journal
Background: Osteoporosis is a common and important complication of Crohn's disease. The risk of osteoporosis is known to be related to body mass index, use of corticosteroid therapy and disease activity. These factors do not fully account for the variation between patients, genetic factors may also be important. Aim: To determine whether bone density in Crohn's disease is related to polymorphisms which influence bone density in other conditions: the vitamin D receptor (VDR) Taql (Exon 9), the VDR Start codon polymorphism Fokl (Exon 2) and the Interleukin-6 Nlalll-174 G/C SNPs. The VDR Taql genotype has been found to be related to osteoporosis in postmenopausal women, and bone loss in rheumatoid arthritis. The VDR Fokl genotype and the IL-6 polymorphism have been found to relate to bone mineral density in other populations. Methods: 255 patients had their bone density assessed by DEXA scanning at the lumbar spine and hip. Osteoporosis was defined by WHO criteria as a T(30) score worse than -2.5 at any site, osteopenia as a T(30) score between -1 and -2.5. DNA was genotyped for VDR SNPs, Taql and Fokl, and the IL-6 G/C SNP. Results: There are no significant differences in genotype, or allele frequency between the groups or compared to healthy controls. Conclusion: VDR Taql and Fokl SNPs, and IL-6 G/C SNP do not appear to contribute to the incidence of osteoporosis in Crohn's disease.


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