Card, T.R.; Holmes, G.K.T.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA66
Academic Journal
Background and aims: There is good evidence to suggest that the incidence of Crohn's disease has increased in western nations including the UK since the mid 20th century. Whether this rise is ongoing however is less clear and has been the subject of debate and disagreement for some years now. We have examined changes in Crohn's disease incidence over 30 years in Derby. Methods: All diagnoses of Crohn's disease made at Derby's two DGHs were collected via the use of hospital activity reports, histopathology records and the personal records of gastroenterologists. Diagnoses were validated via hospital notes. Subjects resident outside the city of Derby were excluded. Diagnoses were counted by quinquennia. Official estimates of Derby's population were obtained for the same time periods and used to calculate incidence rates. Results: In total 326 persons living in Derby were diagnosed with Crohn's disease between 1970 and 2000. Of these 131 were male 195 were female. The table shows incidence rates for each quinquennium overall and by site. Conclusions: This study supports the findings of other recent work suggesting that the incidence of Crohn's disease has ceased to rise[2]. An apparent peak in incidence occurred between 1976 and 1990 which predominantly consists of disease involving the colon. The small numbers of cases prevent firm conclusions as to any change in distribution but it is interesting to speculate upon the role of changing diagnostic tests.


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