TITLE

THE NUTRICEUTICAL BOVINE COLOSTRUM FOR THE TREATMENT OF DEXTRAN SULFATE SODIUM INDUCED COLITIS IN RATS

AUTHOR(S)
FitzGerald, A.J.; Marchbank, T.; Boyle, J.; Ghosh, S.; Playford, R.J.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA64
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bovine colostrum is a rich source of nutrients, growth factors and antibodies and is marketed as a health food supplement. There is increasing evidence that it may be useful for the specific treatment of gastrointestinal disease Aims: To examine the effects of a commercially available formulation of colostrum in a rodent model of experimental colitis. Methods: Colitis was induced with 4% dextran sulphate sodium (DSS. Rats were pre-treated with a gavage of either 20 or 60 mg/kg of colostrum before induction of colitis and daily afterwards until killed at 7 days. An addition group was used as controls (no colitis). Disease activity was assessed daily by combining scores of weight lost, stool consistence and bleeding. Colonic tissue was measured and assessed microscopically by histological scoring of inflammation. Results: Treatment with colostrum resulted in a reduction in the disease activity index and intestinal inflammation. Disease activity fell by 11% in the 20 rog/kg group and 34% in the 60 mg/kg group while inflammat on by 60% in the 20 mg/kg group p<0.05) and by 85% in the 60 mg/kg group (p<0.01), compared with the saline gavage control. Conclusion: These preliminary results show improvement in colonic inflammation after administration of colostrum gavage in the rat DSS colitis model.
ACCESSION #
9747722

 

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