THE EFFECT OF SIROLIMUS ON THE NEUTROPHIL OXIDATIVE BURST
- In vitro interaction of caspofungin and immunosuppressives against agents of mucormycosis. Thakur, Manish; Revankar, Sanjay G. // Journal of Antimicrobial Chemotherapy (JAC);Oct2011, Vol. 66 Issue 10, p2312
Objectives Mucormycosis is a rare but refractory mycosis with high mortality. Few therapeutic options are available and novel strategies are needed. Calcineurin inhibitors are known to have antifungal activity, including synergy with various antifungals. We examined the interaction of...
- mTOR regulates pyrimidine synthesis. Trajkovska, Maria // Nature Cell Biology;Apr2013, Vol. 15 Issue 4, p351
The article discusses two studies published in "Science" journal which revealed the role of the mammalian target of rapamycin (mTOR) in regulating the pyrimidine synthesis pathway.
- SAKURA Study 1: Intravitreal sirolimus safe for noninfectious uveitis of posterior segment. Hasson, Matt // Ocular Surgery News;4/25/2015, Vol. 33 Issue 8, p38
The article discusses a study which found the safety and effectiveness of intravitreal sirolimus and is a viable alternative to cortico-steroids in the long-term treatment of chronic noninfectious uveitis of the posterior segment. Topics covered include the role of the injection in the reduction...
- Autophagy Induction by Endothelial-Monocyte Activating Polypeptide II Contributes to the Inhibition of Malignant Biological Behaviors by the Combination of EMAP II with Rapamycin in Human Glioblastoma. Jun Ma; Fanjie Meng; Shuai Li; Libo Liu; Lini Zhao; Yunhui Liu; Yi Hu; Zhen Li; Yilong Yao; Zhuo Xi; Hao Teng; Yixue Xue; Braun, Ralf J.; Zhongya Wang // Frontiers in Molecular Neuroscience;Dec2015, p1
This study aims to investigate the effect of endothelial-monocyte activating polypeptide II (EMAP II) on human glioblastoma (GBM) cells and glioblastoma stem cells (GSCs) as well as its possible mechanisms. In this study, EMAP II inhibited the cell viability and decreased the mitochondrial...
- Nature: Charting autism's neural circuitry. // Biomedical Market Newsletter;7/19/2012, Vol. 21, p1
The article discusses the immunosuppressant drug called rapamycin that can prevent autistic-like symptoms caused by the deletion of a single gene from the cerebellum.
- Immunosuppressants. // Reactions Weekly;7/31/2010, Issue 1312, p29
The article describes the cases of eight solid organ transplant recipients who developed phaeohyphomycosis due to Alternaria species while undergoing immunosuppression treatment with mycophenolate, mofetil, tacrolimus, prednisone, sirolimus, azathioprine and ciclosporin.
- Immunosuppressants. // Reactions Weekly;10/1/2011, Issue 1371, p20
The article describes the case of a 65-year-old man who developed sepsis after receiving immunosuppressive therapy for cryoglobulinaemia.
- Antibacterials/immunosuppressants. // Reactions Weekly;5/19/2012, Issue 1402, p10
The article describes the case of a 43-year-old man who developed neutropenic sepsis, an influenza A virus H1N1 subtype infection and Aspergillus flavus pneumonia following immunosuppressant and antibacterial admministration.
- All Roads, as We Know, Lead to MTOR. Breindl, Anette // BioWorld Today;8/5/2013, Vol. 24 Issue 148, Special section p2
The article discusses research which implicated mammalian target of rapamycin (mTOR) signaling in the resistance of tumor cells to separate classes of therapeutics, which appeared in the August 1, 2013 issue of "Science Translational Medicine."