TITLE

Clinico-laboratorial and ultrastructurial evaluation of modern antihelicobacterial complexes in peptic ulcer patients treatment

AUTHOR(S)
Degtjaryova, I.I.; Skrypnyk, I.N.
PUB. DATE
September 2002
SOURCE
Gut;Sep2002 Supplement 2, Vol. 51, pA64
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Helicobacter pylori (HP) — eradication at peptic ulcer (PU) is of great meaning, because HP increases the relapses frequency, the danger of the illness. Threefold therapy consisting of Rabeprasole-R (Pariet), Clarithromycin-C (Klacid), Amoxicillin-A (Flemoxin-solutab) possesses high antihelicobacterial activity. Aims: to investigate the efficiency of application of R+C+A for curing PU patients, the influence of these drugs' combination on ulcer healing, ultrastructure of gastric mucosa (GM), relationships of aggressiveness (AF) and defense factors (DF) in gastric juice, HP- eradication. 83 duodenal PU patients were investigated. Healing of ulcer with soft scar was observed in two weeks in 61 (73.5%), in four weeks — 83 (100%) patients. After treatment the HP-eradication was observed in 79 (95.2%) patient, average round-the-clock pH stomach body increased from 1.5±0,4 to 4.9±0.5. AF — the relationship between the proteolytic activity and the total pepsin concentration was decreased. Before treatment AF was 0.91±0.08, after treatment — 0.42±0.05; normal 0.3±0.04. After treatment gastric juice DF — relationship between the mucous protein concentration and proteolytic activity increased. DF before treatment 0.81plusmn;0.04; after treatment -2.51±0.07; normal 2.87plusmn;0.06. Parietal cells of the GM were found in the state of high functional activity before curing. Mucous granules of the cover epitheliocytes were often subjected to degeneration and formed the whole secretory fields. After treatment an active regeneration of the cover cells of epithelium was observed in the GM. Parietal cells were found to be in the state of functional rest. Mucous producing cells were in active state and contained many secretory granules to the apical parts. Chief, must cells in the state of the mild activity. There were many small interepithelium lymphocytes in GM, which evidenced its active proliferation....
ACCESSION #
9747673

 

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