THE IDENTIFICATION OF P53 MUTATIONS IN METAPLASTIC BARRETT'S TISSUES: A PROGNOSTIC MARKER?
- Detection of p53 mutations in precancerous gastric tissue. Morgan, C.; Jenkins, G.J.S.; Ashton, T.; Griffiths, A.P.; Baxter, J.N.; Parry, E.M.; Parry, J.M. // British Journal of Cancer;10/6/2003, Vol. 89 Issue 7, p1314
Intestinal-type gastric cancer is preceded by gastritis and intestinal metaplasia. There is uncertainty regarding the stage at which genetic alterations in the p53 gene occur. Reactive oxygen species (ROS) may participate in the production of mutations and the inactivation of p53 is due to...
- Korelacija izmeÄ‘u ekspresije p53 i kliniÄkopatoloÅ¡kih osobina karcinoma Å¾eluca. Radovanović, Dragče; Knežević, Milan; Čanović, Dragan; Aćimović, Ljubiša // Vojnosanitetski Pregled: Military Medical & Pharmaceutical Journ;Oct2011, Vol. 68 Issue 10, p832
Backgraund/Aim. Gene p53, or "cell genome keeper", has a preventive effect on the occurrence of genetic aberrations and prevents abnormal expansion of (tumor) cells. In gastric cancer cells in most cases we register high expression of mutated p53 gene, which correlates with prognosis and...
- Function and Sequence Analyses of Tumor Suppressor Gene p53 of CHO.K1 Cells. Tzang, Bor-Show; Lai, Yi-Chyi; Hsu, Mandy; Chang, Hsueh-Wei; Chang, Chia-Chin; Huang, Pien C.; Liu, Yin-Chang // DNA & Cell Biology;Apr99, Vol. 18 Issue 4, p315
The tumor suppressor gene p53 plays an important role in guarding genomic integrity. When induced in response to environmental results, the gene product of p53 functions as a transcription factor to transactivate genes involved in arresting the cell cycle and as a facilitator of DNA repair. In...
- N-myc Modulates Expression of p73 in Neuroblastoma. Xiaoxiang Zhu; Wimmer, Katharina; Kuick, Rork; Lamb, Barbara J.; Motyka, Stephanie; Jasty, Rama; Castle, Valerie P.; Hanash, Samir M. // Neoplasia;Sep/Oct2002, Vol. 4 Issue 5, p432
Deals with a study which investigated the influence of the N-myc gene on the expression of the p53 homologue, p73. Materials and methods; Results; Discussion.
- The role of p53 in terminal epithelial cell differentiation. Saifudeen, Zubaida; Dipp, Susana; El-Dahr, Samir S. // Journal of Clinical Investigation;4/15/2002, Vol. 109 Issue 8, p1021
Provides evidence implicating the tumor suppression protein p53 in terminal differentiation of the renal epithelium. Methods; Information on the binding of p53 to renal function gene promoters; Discussion.
- P53 tumor suppressor gene: At the crossroads of molecular carcinogenesis, molecular epidemiology... Harris, Curtis C. // Environmental Health Perspectives Supplements;May96 Supplement 3, Vol. 104, p435
Studies the p53 tumor suppressor gene. Samples of tumor suppressor genes involved in human cancer; DNA damage; bioethical issues; Human cancer risk assessment; Intervention and risk management.
- Genomic instability, mutators and the development of cancer: Is there a role for p53? Fishel, Richard // JNCI: Journal of the National Cancer Institute;11/20/96, Vol. 88 Issue 22, p1608
Editorial. Examines the role of the p53 antioncogene in carcinogenesis. Regulation of genomic stability; Evidences supporting and opposing p53's role in genomic stability/instability.
- P53 Regulation: Hitting the G spot. Brooksbank, Cath // Nature Reviews Cancer;Jun2002, Vol. 2 Issue 6, p405
Examines the role of cyclin G in p53 regulation. Effect of the binding of cyclin G to protein phosphatases; Colocalization of cyclin G with p53 targets.
- Cancer: Pinning a change on p53. Ryan, Kevin M.; Vousden, Karen H. // Nature;10/24/2002, Vol. 419 Issue 6909, p795
Reports on the involvement of an enzyme called Pin1 in activating the p53 protein that helps to prevent the development of malignancies. Functions performed by p53; Explanation of the regulation process of p53 protein by Pin1.