TITLE

ANALYSIS OF THE CC CHEMOKINE RECEPTOR CCR5 δ32 MUTATION IN BEHCET'S DISEASE

AUTHOR(S)
Yang, X.; Ahmad, T.; Gogus, F.; Wallace, G.; Madanat, W.; Kanawati, C.A.; Yazici, H.; Marshall, S.E.; Jewell, D.P.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA55
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Behcet's disease (BD) is a chronic multi-system inflammatory disorder characterized by recurrent oral and genital inflammation, uveitis and pathergy. Reports of an association between HIV-I infection and BD suggest that retroviruses may play a role in the pathogenesis of this disease. Chemokine receptor CCR5 acts as a co-receptor permitting entry of the HIV-1 virus into CD4-positive T cells. Here we investigate whether a 32bp deletion of this gene (CCR5 832), implicated in susceptibility to, and progression of, HIV disease, is associated with BD. Methods: We studied 350 BD patients and 559 healthy ethnically matched controls recruited from 3 ethnic groups (Turkish: 109 BD, 96 controls; Palestinian 100 BD, 98 controls; UK white Caucasian: 131 BD, 365 controls). Genotyping for the CCR5 δ32 deletion was perfomed using PCR-SSP. Data were stratified by the presence of HLAB[sup *]51, an allele previously shown to be associated with BD in the 3 ethnic groups. Results: The CCR5 832 allele was significantly more common in UK white Caucasians than in either the Turkish or Palestinian cohorts (control allele frequency 14.2%, 4.2% and 0.5% respectively: P<1×10[sup 8]). No association was found with the CCR5 832 allele and BD in any of the three cohorts, even when stratified by the BD associated allele HLA-B[sup *]51. Conclusions: The CCR5 δ32 allele is common in UK white Caucasians but rare in both Turkish and Palestinian populations. The CCR5 δ32 allele is not associated with Behcet's disease in white UK Caucasians, Turkish, or Palestinian populations.
ACCESSION #
9747648

 

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