TITLE

Inflammation and intestinal metaplasia of cardiac mucosa in patients with duodenal ulcer disease and reflux esophogitis

AUTHOR(S)
Michopoulos, S; Petraki, K.; Sotiropoulou, M.; Natsios, A.; Katsakos, N.; Manthos, G.; Stamatis, G.; Sgouras, D; Kralios, N.; Mentis, A.
PUB. DATE
September 2002
SOURCE
Gut;Sep2002 Supplement 2, Vol. 51, pA60
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim of the study: To evaluate possible differences in inflammation and intestinal metaplasia in patients with duodenal ulcer (DU) and reflux esophagitis (RE). Patients and Methods: 90 patients with DU, all Hp(+) and 98 patients with RE, 54 Hp(+) and 44 Hp(-) were enrolled in the study. Biopsy specimens obtained from gastric antrum (A), fundus (F) and cardia(C) were examined with Hematoxylin-Eosin, modified Giemsa, PAS-Alcian Blue and HID-Alcian Blue stains. The grade and activity of inflammation were evaluated according to updated Sydney System. Serology for CagA characterization was performed in all Hp(+) patients. Stat: chi-square. Results: The number of patients with the different degrees (0/1/2/3) of the grade and the activity of inflammation as well as the presence and the extent of intestinal metaplasia (IM) are shown in the table. CagA seropositivity was 90% for DU patients but only 40% for REHp(+). Conclusions: 1) The grade and activity of the inflammation of the cardia are more severe in DU than in REHp(+) patients. 2) The grade and activity of the cardia inflammation are more severe in REHp(+) than in REHp(-) patients. 3) There is no difference in the presence of IM neither between DU and REHp(+) nor between REHp(+) and REHp(-) patients. 4) the prevalence of CagA seropositivity is higher in DU than in REHp(+) patients.
ACCESSION #
9747635

 

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