Inflammation and intestinal metaplasia of cardiac mucosa in patients with duodenal ulcer disease and reflux esophogitis

Michopoulos, S; Petraki, K.; Sotiropoulou, M.; Natsios, A.; Katsakos, N.; Manthos, G.; Stamatis, G.; Sgouras, D; Kralios, N.; Mentis, A.
September 2002
Gut;Sep2002 Supplement 2, Vol. 51, pA60
Academic Journal
Aim of the study: To evaluate possible differences in inflammation and intestinal metaplasia in patients with duodenal ulcer (DU) and reflux esophagitis (RE). Patients and Methods: 90 patients with DU, all Hp(+) and 98 patients with RE, 54 Hp(+) and 44 Hp(-) were enrolled in the study. Biopsy specimens obtained from gastric antrum (A), fundus (F) and cardia(C) were examined with Hematoxylin-Eosin, modified Giemsa, PAS-Alcian Blue and HID-Alcian Blue stains. The grade and activity of inflammation were evaluated according to updated Sydney System. Serology for CagA characterization was performed in all Hp(+) patients. Stat: chi-square. Results: The number of patients with the different degrees (0/1/2/3) of the grade and the activity of inflammation as well as the presence and the extent of intestinal metaplasia (IM) are shown in the table. CagA seropositivity was 90% for DU patients but only 40% for REHp(+). Conclusions: 1) The grade and activity of the inflammation of the cardia are more severe in DU than in REHp(+) patients. 2) The grade and activity of the cardia inflammation are more severe in REHp(+) than in REHp(-) patients. 3) There is no difference in the presence of IM neither between DU and REHp(+) nor between REHp(+) and REHp(-) patients. 4) the prevalence of CagA seropositivity is higher in DU than in REHp(+) patients.


Related Articles

  • nizatidine.  // Royal Society of Medicine: Medicines;2002, p395 

    This article presents information on the drug nizatidine. It can be used to assist in the treatment of benign peptic ulcers, relieve heartburn in cases of reflux oesophagitis and a variety of conditions where reduction of acidity is beneficial. The drug should not be used until a full diagnosis...

  • Axid.  // Royal Society of Medicine: Medicines;2002, p94 

    This article presents information on Axid, a proprietary, prescription-only preparation of the H[sub2]-antagonist tnizatidine, from Lilly. Axid can be used as an ulcer-healing drug for benign peptic ulcers in the stomach or duodenum, gastro-oesophageal reflux, dyspepsia and associated...

  • Cross-national changes in the effects of peptic ulcer disease. Bloom, Bernard S.; Bloom, B S // Annals of Internal Medicine;4/1/91, Vol. 114 Issue 7, p558 

    Objective: To describe and to analyze the changing effects of peptic ulcer disease over time.Design: Variables relating to peptic ulcer disease from 1970-1986 were compared. The variables included rates of mortality, hospitalizations, operations, physician visits, and...

  • The impact of H. pylori status on healing of erosive and non-erosive GERD with Esomeprazole: an analysis based on the ProGERD Study initiative. Malfertheiner, P.; Leodolter, A.; Vieth, M.; Jaspersen, D.; Labenz, J.; Meyer-Sabellek, W.; Willich, S.N.; Lind, T.; Stolte, M. // Gut;Sep2002 Supplement 2, Vol. 51, pA65 

    Background: The ProGERD study initiative is based on a large multicenter clinical trial conducted in Germany. The aim is to follow, over a 5 year period, the clinical evolution of patients with non-erosive and erosive gastroesophageal reflux disease (GERD) after treatment with esomeprazole 20 mg...

  • What's Hot in the Red Journal This Month.  // American Journal of Gastroenterology;Mar2013, Vol. 108 Issue 3, p293 

    An introduction is presented in which the editor discusses various reports within the issue on topics including gastroesophageal reflux disease, gastric acid secretion and peptic ulcer bleeding.

  • Indigestion: When is it functional? Talley, Nicholas J; Nghi Phung; Kalantar, Jamshid S // BMJ: British Medical Journal (International Edition);12/1/2001, Vol. 323 Issue 7324, p1294 

    Discusses the diagnosis and treatment of dyspepsia. Various symptoms of the condition, including heartburn, abdominal pain, and acid regurgitation; Causes of dyspepsia, including gastro-esophageal reflux disease, peptic ulcers, gastric cancer, and gall stones; Pathogenesis, identification and...

  • Is duodenogastroesophageal reflux implicated in Barrett’s esophagus?1 1Avidan B, Sonnenerg A, Schnell TG, Sontag SJ Gastric Surgery Is Not a Risk for Barrett’s Esophagus or Esophageal Adenocarcinoma Gastroenterology 2001;121:1281–5 Lehrer, Jenifer K.; Katz, Philip O. // American Journal of Gastroenterology;Sep2002, Vol. 97 Issue 9, p2463 

    This retrospective case-control study was designed to help identify whether gastric surgery for benign peptic ulcer disease increases the risk of developing Barrett’s esophagus (BE). A case population of 650 patients with short-segment BE and 366 patients with long-segment BE were...

  • Increase of reflux esophagitis and decrease of peptic ulcer disease and Helicobacter pylori infection between 1994 and 2001. Sacca, N.; Rodino, S.; De Medici, A.; D'Amico, T.; Fragomeni, A.; Giglio, A. // Gut;Sep2002 Supplement 2, Vol. 51, pA36 

    In the past years the prevalence of of reflux esophagitis has been increasing, whereas the prevalence of ulcer peptic disease has been decreasing. In this study we analyzed, retrospectively, the patients who underwent endoscopy, in our Unit, in the years 1994-1997-2001. We studied clinical and...

  • Helicobacter pylori (HP) eradication does not cause esophagitis in healthy blood donors: 8 years follow-up. Ricci, C.; Vaira, D.; Rugge, M.; Russo, V.; Leandro, G.; Gatta, L.; Menegatti, M.; Tampieri, A; Miglioli, M.; Vakil, N. // Gut;Sep2002 Supplement 2, Vol. 51, pA42 

    Background: there is controversy about whether HP eradication causes erosive esophagitis but most studies have been limited by short follow-up and pre-existing ulcer disease. Aim: to determine the incidence of endoscopic esophagitis in asymptomatic blood donors who underwent eradication therapy...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics