THE ROLE OF PPAR[sub Î³] IN THE ANTI-COLORECTAL CANCER ACTIVITY OF INDOMETHACIN
- Invited Commentary. Gieseler, Frank // International Journal of Colorectal Disease;Mar2000, Vol. 15 Issue 2, p112
Presents a commentary about the dilemma of gastroenterological oncology. Emphasis on nonsteroidal anti-inflammatory drugs; Correlation between chronic inflammatory conditions of the bowel and the development of colon carcinoma; Indomethacin treatment of colon carcinoma cells.
- Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copperâ€“indomethacin in rats. Bonin, Antonio M.; Yáñez, Jaime A.; Fukuda, Chie; Xiao Wei Teng; Dillon, Carolyn T.; Hambley, Trevor W.; Lay, Peter A.; Davies, Neal M. // Cancer Chemotherapy & Pharmacology;Sep2010, Vol. 66 Issue 4, p755
To evaluate, for the first time, the efficacy of copperâ€“indomethacin in the inhibition of aberrant crypt foci formation using the azoxymethane-induced adenocarcinoma model, to examine cell viability in the HCT-116 colorectal cancer cell line, gastrointestinal permeability, mitochondrial...
- Synthesis and evaluation of nicotinic acid conjugate of indomethacin as a safe non-steroidal anti-inflammatory drug. Gund, Machhindra; Khan, Fazlur-Rahman Nawaz; Khanna, Amit // Journal of Pharmacy Research;Oct2011, Vol. 4 Issue 10, p3275
Indomethacin (1) underwent esterification with 3-bromopropanol in the presence of Cs2 CO3 in DMF at 0 Â°C to afford its corresponding ester derivative (2) which then condensed with nicotinic acid chloride in the presence of triethylamine and dichloromethane to afford the ester derivative (3)....
- THE MOLECULAR MECHANISM OF ACTION INDUCED BY IBUPROFEN AND INDOMETHACIN ON HUMAN COLORECTAL CANCER CELL LINES. Khoo Boon Yin; Nor, Norazmi Mohd.; Yaacob, Nik Soriani // Malaysian Journal of Medical Sciences;Jan2007 Supplement, Vol. 14, p175
Introduction: Non-steroidal anti-inflammatory drugs (NSAIDs) exert anti-colorectal cancer (CRC) activity by inhibiting the cyclooxygenase-2 (COX-2) expression. However, inhibition of the activity of COX-2 alone is insufficient to induce apoptosis. Other factor such as peroxisome...
- Synergistic effect of indomethacin and NGX6 on proliferation and invasion by human colorectal cancer cells through modulation of the Wnt/Î²-catenin signaling pathway. Qin Guo; Ping Lian; Mantian Liao; Zhiming Xiao; Xiaoyan Wang; Shourong Shen // Molecular & Cellular Biochemistry;Oct2009, Vol. 330 Issue 1/2, p71
AbstractÂ Â This study was designed to investigate whether indomethacin and NGX6 synergistically inhibit the growth and invasiveness of human colon cancer cells (HT-29 and SW620) and to elucidate the molecular mechanism of their action. Cell proliferation was assessed by MTT assay. Cell...
- The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies. Zhou, Dingying; Papayannis, Ioannis; Mackenzie, Gerardo G.; Alston, Ninche; Ouyang, Nengtai; Huang, Liqun; Nie, Ting; Wong, Chi C.; Rigas, Basil // Carcinogenesis;Apr2013, Vol. 34 Issue 4, p943
We have synthesized a novel derivative of indomethacin, phospho-tyrosol-indomethacin (PTI; MPI-621), and evaluated its anticancer efficacy in vitro and in vivo. PTI inhibited the growth of human colon, breast and lung cancer cell lines 6â€“30-fold more potently than indomethacin. In vivo,...
- Screening for novel protein targets of indomethacin in HCT116 human colon cancer cells using proteomics. YAN-LI CHENG; GUI-YING ZHANG; CUI LI; JING LIN // Oncology Letters;2013, Vol. 6 Issue 5, p1222
Non-steroidal anti-inflammatory drugs, such as indomethacin (IN), inhibit colorectal cancer (CRC) growth through cyclooxygenase (COX)-independent mechanisms, however, the precise biological mechanisms are not completely understood. The aim of the present study was to investigate new molecular...
- Spend more time looking for proximal colon cancer, particularly in the elderly. // Modern Medicine;Jan97, Vol. 65 Issue 1, p55
Presents an abstract of the study `Increased incidence of proximal colon cancer in the elderly,' by Y. Ikeda, N. Koyanagi et al published in the September 1996 issue of the `Journal of Clinical Gastroenterology.'
- Detection of mutations associated with colerectal cancer in DNA from whole-gut lavage fluid. Potter, M.A.; Morris, R.G.; Ferguson, A.; Wyllie, A. H. // JNCI: Journal of the National Cancer Institute;04/15/98, Vol. 90 Issue 8, p623
Presents information on the detection of mutations associated with colorectal cancer in DNA from whole-gut lavage fluid. Percentage of overall five-year survival rate for colorectal cancer; Details on the study conducted; Observations made in study.