Wong, P.; Harbord, M.; Jacovicic, M.; Epstein, O.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA49
Academic Journal
Background: In non ulcer dyspepsia (NUD), radionuclide imaging and electrogastrography (EGG) are used to assess gastric emptying (GE) and gastric pacemaker (slow wave) activity respectively. Hypothesis: In NUD, gastric dysrythmias predispose to gastric dysmotility. Aim: (1) To correlate GE and EGG findings in patients with NUD. (2) To correlate GE and EGG with the dominant symptom complex. Methods: A GE study and pre- and post-prandial EGG were performed in 51 patients (34 female; mean age 40 years) with NUD (chronic epigastric symptoms, normal endoscopy, negative Helicobacter pylori and no other cause for symptoms). GE was reported as normal, rapid, or delayed and EGGs as normal (>70% slow waves, with mean frequency of 3 cycles/minute), tachygastria or bradygastria. The symptoms were epigastric pain (n=27); nausea with or without vomiting (N&V) (n=15); epigastric bloating (n=3); nausea and bloating (n=3); and reflux and belching (n=3). Linear regression was used to assess any association between age, gender and symptoms. Results: (1) Both GE and EGG were normal in 12 patients (24%). GE was abnormal in 33 patients (65%) of whom 21 had delayed emptying. The EGG was abnormal in 18 patients (36%), with tachygastria reported in 13. In these 18 patients, the pre-prandial EGG was abnormal in 15, the post-prandial EGG abnormal in 5, whereas GE was normal in 6 (all tachygastrias). (2) GE was abnormal in 16 patients (59%) with pain (delayed in 10), in 11 (73%) with N&V (delayed in 6), in the 3 patients with nausea and bloating (delayed in 2), and delayed in the 3 patients with bloating. GE was normal in the patients with reflux. (3) EGG was abnormal in 12 patients (44%) with pain (tachygastria in 9), in 5 patients (33%) with N&V (bradygastria in 4), and in 1 patient with bloating. There was no corellation between gender, age, GE, EGG, and symptoms. Conclusions: Abnormality of GE or gastric slow wave activity occurs in up to 76% of NUD patients. There appears...


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