TITLE

SENSITIVITY TO ACID REFLUX IN BARRETT'S OESOPHAGUS IS RELATED TO IMPAIRED OESOPHAGEAL MOTILITY

AUTHOR(S)
O'Riordan, J.M.; Byrne, P.J.; Mulligan, E.D.; Keeling, P.W.N.; Reynolds, J.V.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA48
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Patients with Barrett's oesophagus have increased acid and duodenogastric reflux compared to non Barrett's patients. Impaired sensitivity to acid infusion and distension has also been described, but the relationship between oesophageal motility and symptomatology is poorly documented. Methods: 74 patients with Barrett's oesophagus were compared with 216 GORD patients with abnormal acid scores and 50 symptomatic patients who had normal acid exposure. All patients had oesophageal manometry and 24 hour pH monitoring. 36 Barrett's patients also had 24 hour bile monitoring. Symptoms were assessed by event marker and the Symptom Index (SI) was calculated. Analysis was based on the patient's motility status. Results: Barrett's patients with normal motility had significantly less symptoms than GORD patients for similar acid exposure (p<0.01). Barrett's patients with abnormal motility had higher acid exposure than those with normal motility (p<0.01), but the SI values for this group were not significantly different from the GORD patients. Bile reflux in Barrett's oesophagus did not appear to be a significant factor in patient's symptoms. Conclusions: Symptoms in Barrett's oesophagus are less than GORD patients and are related to oesophageal motility. Normal motility in Barrett's oesophagus is associated with the poorest sensitivity and the presence of increased acid exposure is required in order to achieve sensitivity levels comparable with GORD patients.
ACCESSION #
9747591

 

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