Bhandon, P.; Stacey, B.; Bateman, A.C.; Patel, P.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA47
Academic Journal
Introduction: The clinical relevance of cox-2 overexpression in oesophageal adenocarcinoma is uncertain. Aim: To test the hypothesis that cox-2 overexpression in oesophageal adenocarcinoma is associated with decreased patient survival. Methods: Oesophageal resection specimens were obtained from a retrospective sample of patients who underwent intentionally curative resection for oesophageal adenocarcinoma (1990-96). Paraffin sections were used for immunohistochemical staining with a monoclonal antibody for cox-2 (Caymen chemicals) at a dilution of 1/100. Cox-2 expression was assessed using a semi-quantitative intensity-proportion scoring system (H-score i.e. intensity (0-3) × proportion of positive ceils (%); possible scores from 0-300). Statistical analysis was performed using the Mann-Whitney U test and regression analysis. Results: Specimens were identified from 79 patients with full pathological and clinical follow up data (minimum five years). There was a negative association between cox-2 expression and survival (p=0.03). Conclusion: Cox-2 overexpression is a marker of poor survival in patients with oesophageal adenocarcinoma. Differences in survival between groups with high and Iow cox-2 expression were not accounted for by variations in tumour differentiation or nodal stage.


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