Cotton, J.P.; Lopez, M.; McLeod, S.; Todd, J.A.; Johnston, D.A.; Dettmar, P.W.; Dillon, J.F.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA46
Academic Journal
Introduction: GORD affects up to 30% of the population, it is associated with an increased risk of oesophageal adenocarcinoma, a disease that is on the increase. Modern lifestyle has been attributed to the changing epidemiology of oesophageal cancer. We aimed to describe the epidemiology of reflux disease and its complications. Methods: Consecutive consenting patients with symptoms of GORD were recruited from an endoscopy clinic. Demographic data, social habits, and symptom scoring were collected by the administration of a questionnaire, and an upper Gl endoscopy was performed. Oesophagitis was graded using the LA grading system. Results: 1165 subjects were recruited, 615 with no endoscopic features of oesophagitis (EN, 52.7%), 318 with evidence of erosive oesophagitis (EO 27.4%) (LA Grades A 43%, B 33%, C 16%, D 8%) and 232 with Barrett's oesophagus (BO 19.9%). The proportion of male patients was greater in BO subjects (62.5%) than those with EO (52.5%) and EN (35.6%). When stratified for age male subjects with EN, EO, and BO were on average 5 years younger than their female counterparts (P 0.002), and that subjects with BO were 7 years older than those subjects with EN or EO (P 0.002), there was no statistically significant difference in age between those with EN and EO. Although males, regardless of diagnosis, on average drink more alcohol (mean 7.7 units/week, female 1.4 units per week, P 0.001) males and females with BO do not drink more than their counterparts with EN or EO (P > 0.05). There was no difference in pack years smoked between diagnosis and gender. There was no difference in the body mass index beh, veen gender and diagnosis. Conclusions: Male subjects are more likely to develop BO, and they are likely to develop the disease at an earlier age. Tobacco consumption and obesity are not associated with and increased risk of developing BO. Alternatively women may have some protection against developing BO until later in life. Other factors such as...


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