Solaymani-Dodaran, M.; Coupland, C.; Logan, R.F.A.
April 2003
Gut;Apr2003 Supplement 1, Vol. 52, pA45
Academic Journal
Introduction: The relationship between Barrett's oesophagus and extra-oesophageal malignancies (EOM) has been a matter of controversy. Some researchers have pointed out that the incidence of colon cancer is higher in Barrett patients while others have found no such association. The current study explores the relationship between Barrett's oesophagus and EOM in general and colon cancer in particular in 27 813 subjects in General Practice Research Database (GPRD). Methods: The mean follow-up experience was about 6 years and the study subjects constitute four groups: Barrett's oesophagus group (1677), oesophagitis group (6392), simple reflux group (6328), and normal group (13 416). Respectively the last three groups were 4/1, 4/1, and 8/1 matched to the Barrett group according to their GP practice, date of birth and sex. All malignancies occurring before or in the first year after the diagnosis of Barrett's, oesophagitis, or reflux were regarded as prevalent and excluded from the analysis. Risk of occurrence of an unrelated condition such as cataract was also explored for comparison. Number of visits to the GP was defined as a date on which there are both medical and drug records available and its confounding effects were control[ed. Hazard ratios were calculated using Cox-proportional hazard regression analysis. Results: A total of 2167 EOM, 260 colorectal cancer, and 1918 cataract diagnoses were identified in study subjects of which 1119, 113, and 853 cases were excluded respectively as being prevalent. The hazard ratios have been presented in the table after adjusting for age, sex, and number of visits to the GP. Conclusion: The risk of colorectal cancer was not specifically higher in any of these groups. There were small increases in risk of EOM in the Barrett's oesophagus, oesophagitis and reflux groups in comparison to the general population. The explanation for these increases is unclear but they may be mediated by smoking if smoking rates are increased in...


Related Articles

  • Acid reflux impacts quality of life.  // Chain Drug Review;2/13/2012, Vol. 34 Issue 3, p31 

    The article informs that cases of chronic gastroesophageal reflux disease have increased in the U.S. over the past decade.

  • Is It Really Heartburn? Tennesen, Michael // Prevention;Mar2002, Vol. 54 Issue 3, p112 

    Focuses on gastro-esophageal reflux disease (GERD) with information on its symptoms, the potential threat of esophageal cancer, and treatments, including medication and diet changes. INSETS: WHAT ABOUT SURGERY?;HOW MANY CHEESEBURGERS DOES IT TAKE TO GIVE YOU HEARTBURN?.

  • Erratum: Use of a Simple Symptom Questionnaire to Predict Barrett's Esophagus in Patients With Symptoms of Gastroesophageal Reflux. Gerson, Lauren B; Edson, Robert; Lavori, Philips W; Triadafilopoulos, George // American Journal of Gastroenterology;May2014, Vol. 109 Issue 5, p781 

    A correction to the article "Use of a Simple Symptom Questionnaire to Predict Barrett's Esophagus in Patients With Symptoms of Gastroesophageal Reflux" that was published in the previous issue is presented.

  • Oesophagogastric fistula: a post-operative complication. Alzaroa, A.; Kelty, C.; Jacob, G.; White, D. // Gut;Sep2007, Vol. 56 Issue 9, p1225 

    A quiz concerning the diagnosis of a patient with gastroesophageal reflux disease (GORD) is presented.

  • Medical Therapy of Reflux Esophagitis. Castell, Donald O. // Annals of Internal Medicine;Dec80, Vol. 93 Issue 6, p926 

    Comments on the medical therapy of gastroesophageal reflux. Discussion on the treatment of reflux esophagitis; Therapeutic use of bethanechol for treatment of esophagitis; Transition on the therapy of acid peptic disorders.

  • The Pathogenesis of Gastroesophageal Reflux Disease: A Challenge in Clinical Physiology. Cohen, Sidney // Annals of Internal Medicine;12/15/92, Vol. 117 Issue 12, p1051 

    Explores a controversy on the pathogenesis of gastroesophageal reflux disease. Definition of the disease; Reason behind the difficulty of understanding the role of lower esophageal sphincter in the disease; Discussion on patient care.

  • Gastroesophageal Reflux Disease.  // Radiologic Technology;Jan/Feb2010, Vol. 81 Issue 3, p269 

    A quiz concerning gastroesophageal reflux disease is presented.

  • Gastroesohageal Reflux. Richter, Joel E.; Castell, Donald O. // Annals of Internal Medicine;Jul82, Vol. 97 Issue 1, p93 

    Provides information on the pathogenesis, diagnosis and therapy of gastroesophageal reflux. Discussion on pathogenesis of reflux disease; Clinical tests for reflux; Therapy of reflux.

  • Head and Neck Manifestations of Gastroesophageal Reflux Disease. Ahuja, Vanita; Yencha, Myron W. // American Family Physician;9/1/1999, Vol. 60 Issue 3, p873 

    Discusses the manifestation of gastroesophageal reflux disease (GERD). Pathophysiology; Diagnosis; Clinical presentation GERD; Complications.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics