TITLE

LENGTH OF BARRETT'S OESOPHAGUS SEGMENT: DEMOGRAPHIC ASSOCIATIONS AND CANCER RISK

AUTHOR(S)
Gatenby, P.A.C.; Caygill, C.P.J.; Charlett, A.; Fitzgerald, R.; Watson, A.
PUB. DATE
April 2003
SOURCE
Gut;Apr2003 Supplement 1, Vol. 52, pA41
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: Studies have suggested a higher incidence of adenocarcinoma (AC) in longer Barrett's oesophagus (BO) segments, but this has not been stratified. Although AC has been described in short BO segments ≤3cm (SSB), its incidence is controversial. The influence of age, gender, smoking, alcohol, and BMI on the development of BO has been studied in small series, but not their influence on segment length. Methods: Medical records of 1000 BO patients from 5 hospitals registered with UKBOR were examined. Data were extracted on age, gender, BMI, tobacco, and alcohol use, and length of BO segment at BO diagnosis. Data on AC development were also abstracted. Segment lengths were categorised as SSB, >3 ≤6cm and >6cm. The relationships between demographic parameters and segment length, and segment length and AC development were determined, both for overall cancer risk and true incident cancers (occurring >1 year after BO diagnosis). Results: Histology and segment length were available in 625 records. There was a small non-significant increase in BO length with age, but no correlation between gender, BMI, tobacco and alcohol consumption and segment length. The distribution of the 28 overall and 9 incident ACs according to segment length is shown in the table. Conclusions: The risk of both overall and incident cancers is greater for SSB than for segments >3 ≤6cm in length, but the greatest risk is for length >6cm (Pearson χ² p=0.02). Whilst demographic factors have previously shown an influence on the risks of developing BO, there is little correlation with the length of segment which develops.
ACCESSION #
9747544

 

Related Articles

  • Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: molecular mechanisms of carcinogenesis. Toh, Yasushi; Oki, Eiji; Ohgaki, Kippei; Sakamoto, Yasuo; Ito, Shuhei; Egashira, Akinori; Saeki, Hiroshi; Kakeji, Yoshihiro; Morita, Masaru; Sakaguchi, Yoshihisa; Okamura, Takeshi; Maehara, Yoshihiko // International Journal of Clinical Oncology;Apr2010, Vol. 15 Issue 2, p135 

    Esophageal cancer is the eighth most common incident cancer in the world and ranks sixth among all cancers in mortality. Esophageal cancers are classified into two histological types; esophageal squamous cell carcinoma (ESCC), and adenocarcinoma, and the incidences of these types show a striking...

  • Smoking and drinking cessation and the risk of oesophageal cancer. Bosetti, C; Franceschi, S; Levi, F; Negri, E; Talamini, R; Vecchia, C La // British Journal of Cancer;9/1/2000, Vol. 83 Issue 5, p689 

    n a case-control study from Italy and Switzerland with 404 oesophageal cancer cases and 1070 hospital controls, the risk of oesophageal cancer declined with time since cessation of smoking or drinking, and was significantly reduced (odds ratio = 0.11) 10 or more years after cessation of both habits.

  • Attributable Causes of Esophageal Cancer Incidence and Mortality in China. Jian-Bing Wang; Jin-Hu Fan; Hao Liang; Jing Li; Hui-Juan Xiao; Wen-Qiang Wei; Dawsey, Sanford M.; You-Lin Qiao; Boffetta, Paolo; Scheurer, Michael // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Background: To estimate the contribution of tobacco smoking, alcohol drinking, low vegetable intake and low fruit intake to esophageal cancer mortality and incidence in China. Methodology/Principal Findings: We calculated the proportion of esophageal cancer attributable to four known...

  • Alcohol flushing response linked to esophageal cancer risk in Asian population.  // Hem/Onc Today;5/25/2009, Vol. 10 Issue 10, p27 

    The article discusses research on the link between alcohol flushing response and esophageal cancer risk in people of East Asian descent, conducted by P. Brooks et al, published in a 2009 issue of the "PLOS Medicine" journal.

  • Role of retinoic acid receptors in squamous-cell carcinoma in human esophagus. Bergheim, I.; Wolfgarten, E.; Bollschweiler, E.; Hölscher, A. H.; Bode, Ch.; Parlesak, A. // Journal of Carcinogenesis;2005, Vol. 4 Issue 1, p20 

    Background: Worldwide, cancer in the esophagus ranks among the 10 most common cancers. Alterations of retinoic acid receptors (e.g. RARα, β, γ, and RXRα, β, γ) expression is considered to play an important role in development of squamous-cell carcinoma (SCC), which is the most...

  • The Independent Effects of Cigarette Smoking, Alcohol Consumption, and Serum Aspartate Aminotransferase on the Alanine Aminotransferase Ratio in Korean Men for the Risk for Esophageal Cancer. Heejin Kimm; Sangwon Kim; Sun Ha Jee // Yonsei Medical Journal;5/1/2010, Vol. 51 Issue 3, p310 

    Purpose: The goal of this study is to assess the interactions among alcohol consumption, cigarette smoking, and aspartate aminotransferase (AST) / alanine aminotransferase (ALT) ratios on esophageal cancer. Materials and Methods: Alcohol and the risk of incidence and death from esophageal cancer...

  • Cancer of the oesophagus. Nagpal, B. L. // Alive;Aug2015, Issue 394, p109 

    The article offers information on esophageal cancer which occurs over a wide age-group of 20 to over 85 years. Topics include the dietary and environmental factors that cause the cancer including high contents of nitrites and nitrosamines, cigarette smoking, and heavy alcohol consumption,...

  • Body Mass Index, Smoking, and Alcohol and Risks of Barrett's Esophagus and Esophageal Adenocarcinoma: A UK Prospective Cohort Study. Yates, Max; Cheong, Edward; Luben, Robert; Igali, Laszlo; Fitzgerald, Rebecca; Khaw, Kay-Tee; Hart, Andrew // Digestive Diseases & Sciences;Jul2014, Vol. 59 Issue 7, p1552 

    Background: The timing of the risk factors cigarette smoking, alcohol and obesity in the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) is unclear. Aims: To investigate these exposures in the aetiology of BE and EAC in the same population. Methods: The cohort...

  • Role of fried foods and oral/pharyngeal and oesophageal cancers. Galeone, C.; Pelucchi, C.; Talamini, R.; Levi, F.; Bosetti, C.; Negri, E.; Franceschi, S.; La Vecchia, C. // British Journal of Cancer;6/6/2005, Vol. 92 Issue 11, p2065 

    We investigated the role of fried foods on oral-pharyngeal and oesophageal cancers, using data from two case-control studies conducted in Italy and Switzerland between 1992 and 1999, one with a total of 749 (634 men) cases of oral/pharyngeal cancer and 1772 (1252 men) controls, the other with...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics