MUTATIONS OF THE HMSH6 GENE AS A POSSIBLE CAUSE OF HEREDITARY NONPOLYPOSIS COLORECTAL CANCER
- RUNX3 Inactivation in Colorectal Polyps Arising Through Different Pathways of Colonic Carcinogenesis. Subramaniam, Manish M; Chan, Jason Y; Soong, Richie; Ito, Kosei; Yeoh, Khay G; Wong, Reuben; Guenther, Thomas; Will, Olivia; Chen, Chee L; Kumarasinghe, Marian P; Ito, Yoshiaki; Salto-Tellez, Manuel // American Journal of Gastroenterology;Feb2009, Vol. 104 Issue 2, p426
OBJECTIVES:We hypothesized that RUNX3 inactivation by promoter hypermethylation in colorectal polyps is an early molecular event in colorectal carcinogenesis.METHODS:RUNX3 protein expression was analyzed immunohistochemically in 50 sporadic colorectal polyps comprising 19 hyperplastic polyps...
- Cyclooxygenase-2 overexpression is common in serrated and non-serrated colorectal adenoma, but uncommon in hyperplastic polyp and sessile serrated polyp/adenoma. Kawasaki, Takako; Nosho, Katsuhiko; Ohnishi, Mutsuko; Suemoto, Yuko; Glickman, Jonathan N.; Chan, Andrew T.; Kirkner, Gregory J.; Mino-Kenudson, Mari; Fuchs, Charles S.; Ogino, Shuji // BMC Cancer;2008, Vol. 8, Special section p1
Background: Cyclooxygenase-2 (COX-2, PTGS2) plays an important role in colorectal carcinogenesis. COX-2 overexpression in colorectal cancer is inversely associated with microsatellite instability (MSI) and the CpG island methylator phenotype (CIMP). Evidence suggests that MSI/CIMP+ colorectal...
- Polyposis coli and the stomach. // British Medical Journal;10/16/1976, Vol. 2 Issue 6041, p900
Focuses on the contribution of the study of gastrointestinal polyposis to the knowledge of the pathogenesis of colorectal cancer. Rarity of the polyps of the small bowel and gastric adenomas; Suggestions for the physician and surgeon for investigating the upper gastrointestinal tract; Absence...
- Polyp surveillance in patients with limited life expectancy. Koretz, Ronald L. // JAMA: Journal of the American Medical Association;1/24/96-1/31/96, Vol. 275 Issue 4, p327
Responds to an inquiry on colonic polyp surveillance in patients with limited life expectancy. Need to remove and examine the polyp microscopically; Role of the polyp in the reduction of the morbidity and mortality of colon cancer.
- Surveillance for Second Primary Colorectal Cancer after Adjuvant Chemotherapy: An Analysis of Intergroup 0089. Green, Robert J.; Metlay, Joshua P.; Propert, Kathleen; Catalano, Paul J.; Macdonald, John S.; Mayer, Robert J.; Haller, Daniel G. // Annals of Internal Medicine;2/19/2002, Vol. 136 Issue 4, p261
Examines the incidence of secondary colorectal cancer after adjuvant chemotherapy in the U.S. Comparison between secondary and primary colorectal cancer; Determination of adenomatous polyps history; Standard of care for patients with cancer.
- Data support polypectomy's preventive effect. Begany, Timothy // RN;Jun94, Vol. 57 Issue 6, p17
Presents the results of a study published in the `New England Journal of Medicine' on the prevention of colorectal cancer by colonoscopic polypectomy. Reduction in the risk of cancer by removing benign polyps; Study of the actual rate of colorectal cancer in polypectomy patients.
- Evolution of colonic polyps. // British Medical Journal;7/26/1980, Vol. 281 Issue 6235, p257
Reports on the evolution of polyps that can cause colon cancer. Description of the most common type of polyp, adenomas of the colon; Risk of the development of more than one carcinoma in the patients with adenomas; Technique used for the removal of adenomatous polyps; Need for the removal of...
- Screening and Polyp Removal Spur Decline. // USA Today Magazine;Feb2000, Vol. 128 Issue 2657, p11
Reports that a decline in the incidence of colorectal cancer in the United States is due to the screening and removal of precancerous polyps. Correlation between the incidence decline and the increase in screening by colonoscopy; Factors that may have contributed to the declining colorectal cancer.
- Interpreting precursor studies: What polyp trials tell us about large-bowel cancer. Schatzkin, Arthur; Freedman, Laurence S. // JNCI: Journal of the National Cancer Institute;7/20/94, Vol. 86 Issue 14, p1053
Opinion. Analyzes the possible inferences on colon cancer to be drawn from polyp trial findings. Recurrent adenomas as end points; Inferences from adenoma recurrence trials to large-bowel cancer; Inferential implications of a positive finding; Inferential implications of a negative finding;...