HIGHER FREQUENCY OF ZERO TPMT DEFICIENCY: A REVIEW OF TPMT REQUESTS TO A NATIONAL REFERENCE LABORATORY
- In this issue. // Nature Reviews Drug Discovery;Jul2008, Vol. 7 Issue 7, p543
The article discusses various topics published within the issue, including one by Philip Ma and his colleagues on the success of specialty pharmaceuticals and another by Geoffrey Burnstock on the role purinergic signalling in nervous system disorders.
- Poster Abstract #11: Brain Microdialysate and Plasma Concentrations of Inosine During Intravenous Inosine Infusion in Conscious Rats Cusack, Noel; Hurtt, Mark; Katner, Simon; Torchia, John; Solomon, Bruce; Guinn, Robyn; Rohde, Candace; Thorne, Christine // Neurotherapeutics;Jul2008, Vol. 5 Issue 3, p494
Background and Objective: Inosine is an endogenous purine nucleoside with neuroprotective and nerve regenerative properties. The literature suggests that inosine can cross the bloodâ€“brain barrier (BBB) after parental administration, but no direct measurements of CNS interstitial inosine...
- Mining the proteome. // Nature;7/1/2004, Vol. 430 Issue 6995, p109
Reports on Serenex Inc.'s development of proteome mining which promises to deliver unique information about interactions between drug compounds and targets. Profiling of one compound against all targets in an entire sub-proteome; Focus on the purine-binding proteins within the human proteome;...
- Mitigating the risk of skin cancer associated with thiopurine use. Ali, Faisal R.; Lear, John T. // British Journal of Hospital Medicine (17508460);Jan2014, Vol. 75 Issue 1, p55
A letter to the editor in response to an article on thiopurine toxicity in the December 2013 issue is presented.
- The Purinome, a Complex Mix of Drug and Toxicity Targets. J.Haystead, Timothy A. // Current Topics in Medicinal Chemistry;Jun2006, Vol. 6 Issue 11, p1117
Much attention has focused on the development of protein kinases as drug targets to treat a variety of human diseases including diabetes, cancer, hypertension and arthritis. To date, Gleevec is one example of a drug targeting protein that has successfully treated human cancer. Several other...
- Cytotoxic Nucleoside Analogues: Different Strategies to Improve their Clinical Efficacy. Galmarini, C. M.; Popowycz, F.; Joseph, B. // Current Medicinal Chemistry;2008, Vol. 15 Issue 11, p1072
Cytotoxic nucleoside analogues are clinically important anticancer drugs. These agents behave as antimetabolites, compete with physiologic nucleosides, and, consequently, interact with a large number of intracellular targets to induce cytotoxicity. Nucleoside analogues share some general common...
- Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery. Faria, Robson; Ferreira, Leonardo; Bezerra, Rômulo; Frutuoso, Valber; Alves, Luiz // Molecules;Nov2012, Vol. 17 Issue 11, p13009
Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives to synthetic drugs. With several diseases...
- Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum. Cassera, María Belén; Zhang, Yong; Hazleton, Keith Z.; Schramm, Vern L. // Current Topics in Medicinal Chemistry;Aug2011, Vol. 11 Issue 16, p2103
Malaria is a leading cause of morbidity and mortality in the tropics. Chemotherapeutic and vector control strategies have been applied for more than a century but have not been efficient in disease eradication. Increased resistance of malaria parasites to drug treatment and of mosquito vectors...
- Treatment of Retinal Disorders with Purinergic Drugs: Beyond Receptors. Beckel, Jonathan M.; Wennan Lu; Civan, Mortimer M.; Mitchell, Claire H.; Lu, Wennan // Journal of Ocular Pharmacology & Therapeutics;Oct2016, Vol. 32 Issue 8, p488
No abstract available.