CROHN'S DISEASE AND THE NOD2 GENE: A ROLE FOR PANETH CELLS
- Slipping the barrier: how variants in CARD 15 could alter permeability of the intestinal wall and population health. Schreiber, S. // Gut;Mar2006, Vol. 55 Issue 3, p308
The increased intestinal permeability in Crohn's disease is associated with the presence of variants in the CARD15 gene that are regarded as causative for Crohn's disease, suggesting a genetic rather than an environmental background for intestinal Barrier dysfunction in Crohn's disease.
- Adaptive regulation of the ileal apical sodium dependent bile acid transporter (ASBT) in patients with obstructive cholestasis. Hruz, P.; Zimmermann, C.; Gutmann, H.; Degen, L.; Beuers, U.; Terracciano, L.; Drewe, J.; Beglinger, C. // Gut;Mar2006, Vol. 55 Issue 3, p395
Background/aims: The apical sodium dependent bile acid transporter ASBT (SLC10A2) contributes substantially to the enterohepatic circulation of bile acids by their reabsorption from the intestine. In the rat, its adaptive regulation was observed in the kidneys, cholangiocytes, and terminal ileum...
- Acute ileitis. Morain, C.Q. // British Medical Journal (Clinical Research Edition);10/24/1981, Vol. 283 Issue 6299, p1075
Focuses on the distinction of acute ileitis from Crohn's disease. Cause of acute terminal ileitis; Relation of fistula formation in Crohn's disease to the severity of the disease in the ileum; Procedures to the diagnosis of Crohn's disease.
- Crohn Disease. Dworken, Harvey J. // Annals of Internal Medicine;Aug84, Vol. 101 Issue 2, p258
Discusses Crohn disease. Findings of a study that dealt with the association between Crohn disease, psychiatric disabilities and personality types; Organisms that might rarely produce a form of chronic colitis that are vaguely suggestive of Crohn disease; Treatment of patients with Crohn disease.
- Management of Crohn's disease. Rampton, David S. // BMJ: British Medical Journal (International Edition);12/04/99, Vol. 319 Issue 7223, p1480
Reviews the management of adults with common presentations of Crohn's disease. Aetiopathogenesis of Crohn's disease; Treatment of active ileocaecal Crohn's disease and other common active presentations; Maintenance of remission of Crohn's disease.
- Extraintestinal Crohn's disease: Case report and review of the literature. Ulnick, Keith M.; Perkins, Jonathan // ENT: Ear, Nose & Throat Journal;Feb2001, Vol. 80 Issue 2, p97
Crohn's disease is a granulomatous inflammatory bowel disease. Its pathologic findings include noncontiguous chronic inflammation and noncaseating granulomas. Any segment of the gastrointestinal tract can be involved, but it is uncommon to find that Crohn's disease has spread beyond the...
- Ileal Crohn's disease is best treated by surgery. Windsor, A.C.J. // Gut;Jul2002, Vol. 51 Issue 1, p11
Argues that ileal Crohn's disease can only be managed when surgical intervention is complemented with a relief of symptoms and minimization of the risks of therapy and disease recurrence. Definition of the optimal time for surgical intervention; Consequences of long-term medical therapy in...
- Ileal Crohn's disease is best treated by surgery. Farthing, M.J.G. // Gut;Jul2002, Vol. 51 Issue 1, p13
Questions the need for surgical intervention in the management of ileal Crohn's disease. Endoscopic, clinical and surgical relapse rates after ileal resection; Availability of effective medical therapy for active ileal Crohn's disease, maintenance of remission and possibly for prevention of...
- Hidradenitis Suppurativa and Crohn's Disease in Two Families: A Significant Association? Gower-Rousseau, C.; Maunoury, V.; Colombel, J. F.; Coulom, P.; Piette, F.; Cortot, A.; Paris, J. C. // American Journal of Gastroenterology;Jul1992, Vol. 87 Issue 7, p928
Presents a letter to the editor regarding hidradenitis suppurativa in Crohn's disease.